TMJ vs Teeth Grinding – InVite Health Podcast, Episode 528
Are you grinding your teeth or do you have TMJ? Many people confuse these two issues. Find out how they are different and what you can do to help from Amanda Williams, MD, MPH.
Tag: vitamin C
Birth Control Pills and Vitamin Deficiencies – InVite Health Podcast, Episode 514
If you’re taking a birth control pill, you may be losing important nutrients that your body needs to function properly.
Impact of Moderate Alcohol Consumption – InVite Health Podcast, Episode 510
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Please see below for a complete transcript of this episode.
Impact of Moderate Alcohol Consumption – InViteⓇ Health Podcast, Episode 510
Hosted by Amanda Williams, MPH
*Intro music*
InVite Health Podcast Intro: Welcome to the InViteⓇ Health Podcast, where our degreed healthcare professionals are excited to offer you the most important health and wellness information you need to make informed choices about your health. You can learn more about the products discussed in each of these episodes and all that InViteⓇ Health has to offer at www.invitehealth.com/podcast. First time customers can use promo code PODCAST at checkout for an additional 15% off your first purchase. Let’s get started!
*Intro music*
Amanda Williams, MD, MPH: [00:00:40] We’ve all heard that you shouldn’t over consume alcohol. Today, I want to talk about the physiological impact that alcohol consumption actually has on the body and the different nutrients that can be impacted or influenced by the consumption of alcohol. And then obviously, if you’re going to be consuming alcohol, what nutrients would certainly be advisable to to have on board to help your little cells recover from that. I’m Amanda Williams, MD, MPH, and this is an important topic, and I have a lot of people who will ask me this question, “You know, I… Oh, I, you know, have social drinks once or twice a week. And you know, what concerns should I have?” Obviously, we always want to focus on the liver, but we have to look at the bigger picture. And the bigger picture is, is that we know certainly when it comes to alcohol consumption in the United States, it’s pretty high. You know, according to surveys and statistics, we know that it’s probably about 86% of people over the age of 18 have, you know, at some point in time their life consumed alcohol and then you’re going to have, you know, different periods in people’s lives where perhaps alcohol consumption is greater or less. And there’s always concern when it comes to binge drinking or, you know, heavy alcohol use at one given time like they used to always have, you know, Blackout Wednesdays, which was the the Wednesday before Thanksgiving where all college, you know, kids were back in their hometowns and hitting up the local bars. And so you could see these trends that occur and we we can even see just based off of alcohol sales, you know, New Year’s obviously is going to be the biggest, but we just, you know, have to look at the the impact of social drinking, as we shall say, because we know what happens when we have chronic abuse of alcohol, so alcoholism itself. But when we’re just looking at, say, social drinking, and if someone is doing that responsibly, we still have to think about the long-term implications that can occur from the intake of alcohol and how the body’s actually metabolizing that.† [00:02:59]
[00:03:00] So all of these things are important factors because there’s many moving parts. We know that most of the alcohol passes into the small intestine and it’s absorbed rapidly into the blood, which is why blood alcohol levels, you know, for the most part, are pretty good indication as to how fast your body is taking in that. We know that the conversion of alcohol into acetaldehyde occurs predominantly in the liver through an enzymatic pathway regulated through something called alcohol dehydrogenase. So the alcohol dehydrogenase converts into acetaldehyde. Now remember, acetaldehyde is not our friend. This is oftentimes what creates that headache or that nauseousness that people can get after consuming or overindulging in alcohol. Or if we think about a hangover, this is because of acetaldehyde, this toxin, this neurotoxin that builds up, and we can see that that acetaldehyde that’s produced from the alcohol, it’s converted by an enzyme known as aldehyde dehydrogenase into acetate, and the acetate can be utilized for energy throughout the body. So there’s a lot of moving parts, and the main thing to focus in on is what is actually happening, what is occurring. So we know that there’s these different pathways. You know, you go in, you get your wine, you get your vodka, you get your beer, whatever it is that you’re choosing to drink. And this is going through the intestinal absorption, the, you know, immediate release of that alcohol into the bloodstream. If you have these different moving parts, these different pathways for the breakdown. And then we have this byproduct that’s created, that acetaldehyde.† [00:04:49]
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[00:04:51] Now the problem is, is that many people when they get a unwanted side effect from overconsumption of alcohol, they right away want to turn towards like a NSAID, a non-steroidal anti-inflammatory drug like, you know, ibuprofen or, you know, taking aspirin. But we know that, you know, this can lead to issues in terms of, you know, GI issues. And if someone already has underlying GI inflammation, it’s probably not the best. Now, acetaminophen is definitely the worst because acetaminophen is directly detrimental to, to the liver itself. So when we think about liver toxicity, acetaminophen or your Tylenol is the, is the one that will create the most havoc when it comes to liver. So if the liver is already stressed out because you just poured in a bunch of alcohol into your system, the last thing you want to be turning to is acetaminophen. So this is key.† [00:05:55]
[00:05:56] I’m talking about the subject ’cause I get so many questions about this on a regular basis is, “What should I do? I’m not going to not have a drink with my friends. I’m going to go out and I’m going to, you know, be around family or friends or whatever, be the case, and I’m going to have one or two drinks and this may happen one or two times a week or whatever the case may be. So what do I need to be doing?” So this is when we look at, you know, finding out which nutrients in particular can become depleted through alcohol use. We know that B-vitamins… yes, 100%. You can see this in alcoholism, where B1 in particular really takes a hit. And this is a major concern even in the setting of social drinking. So B-vitamins is something that, if you are going to be indulging in your alcohol, make sure that you are taking your B-vitamins. But we can also look at how other nutrients minerals such as selenium, for example, Vitamin E can also take a hit when it comes to the way that that alcohol is being processed in the body. So these are all things just to to be cognizant of.† [00:07:07]
[00:07:08] The biggest problem that many people will recognize when it comes to alcohol consumption is a hangover. So when we get that buildup acetaldehyde and you, you get that dizziness, you, you know, maybe have a headache, there’s a, you know, irritability, there’s a lot of different ways in which a hangover can present from one person to the next. But we certainly know that a hangover can impact your normal functional status and through the way that the alcohol itself is being metabolized in that buildup of that toxin, that actual toxin that is created, acetaldehyde, this is what is incredibly problematic. So how do we rid the body of this? This is kind of the key thing. Well, we know that our B-vitamins are important when it comes to metabolic detoxification for enhancing our natural antioxidants. So clearly, we have to look and say OK, if our antioxidants are not able to keep up with the demand that the alcohol is putting on that, then obviously we need to be looking at antioxidants putting those back in, including things such as glutathione. And so we would then look at more than likely we’d be looking at utilization of N- acetyl cysteine. This is going to be usually the best option when it comes to the reestablishing proper glutathione on stores. But we also want to look at things like Vitamin C, your B-vitamins, Vitamin E, for example.† [00:08:39]
[00:08:41] Inflammation is key when we think about alcohol consumption. Many times people don’t recognize the dangers, and this is why I say, you know, even social drinking can lead to harmful effects within our vascular system. But understanding that inflammation is going to be generated through the consumption of alcohol. So the alcohol itself creates this increased permeability within the intestinal lining. So when we talk about leaky gut, for example. So this is allowing these different endotoxins to pass into the bloodstream, which is then going to trigger an inflammatory response. So when we have these inflammatory cytokines traversing through the body along with the alcohol, now we’ve created a real problematic situation. So through the stimulation of the inflammatory system, this is where a lot of that cellular injury can occur. And it’s not just limited to the liver. We can look at the vascular system in particular. We can certainly look at our nervous system and within the brain. So looking at how we can minimize this, how do we minimize this? Well, number one, try to not drink or if we’re drinking very moderately. Obviously, having foods that can offset the acetaldehyde, things such as green tea is a really excellent choice when it comes to the mitigation of the harmful effects of acetaldehyde and the buildup of that. So if someone’s going to be drinking, I always say it may not be a bad idea to be considering green tea in conjunction. So maybe switch on and off. You have your alcoholic drink and then you have your green tea, so Green Tea TxⓇ, White Tea TxⓇ, excellent options for you.† [00:10:36]
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[00:10:36] And then we want to look at those key nutrients, so we have to look at the B-vitamins. We know that those B-vitamins are so critical to so many different functions in our body when it comes to our immune defenses, when it comes to the way that our brain and the neuronal connections work when it comes to the release of certain key neurotransmitters. So definitely a B-complex is incredibly advantageous. And even if you’re one of those folks where maybe you just go out and you’re drinking, you know, once a week or once a month, make sure that around that time that you are going to be consuming your alcohol, that at minimum you are on your multivitamin. But I would definitely advise being on the methylated B. So the InViteⓇ Methyl-B, the activated B-vitamins to really try to help to offset that would certainly be advantageous. Then we have to think about the antioxidant response, and this is where NAC would come into play to really give the the liver that support when it comes to bolstering up its antioxidant defense system via glutathione. So N-acetyl cysteine, certainly important. We have to look at how Vitamin E is known to be depleted in the presence of alcohol. So having natural Vitamin E as part of a supplementation routine, if you are more of that moderate social drinker, then definitely, you know, Vitamin E is something that you would want to be having into your routine. I had mentioned the mineral selenium. This is another thing. If we have inadequate selenium, we are once again going to disturb the proper functioning of how glutathione is processed and released. So in the absence of selenium we’re once again setting our body up into a state where we have a lower antioxidant defense system. So taking the multivitamin, which contains that selenium, will help to cover that basis as well. Your Vitamin C certainly is going to be beneficial.† [00:12:44]
[00:12:45] Thinking about the different targeted nutrients that we know are very friendly to our little hepatocytes, our liver cells, things like milk thistle, for example. The flavonoids contained within that milk thistle certainly can be very beneficial when it comes to targeting the inflammation that is driven up within the body. And then obviously looking at things like resveratrol, grape seed extract are all excellent choices, and we have to also look at the structural damage that can occur within the cells, not only just within the liver, but when we think about, you know, throughout the brain, throughout the vascular system. So we want to make sure that we have good omega-3 fatty acids on board. Certainly going to be quite advantageous to to maintain the health of that cellular membrane. So in combination, there’s a lot of different nutrients we have to look at, you know, the big ones being your B-vitamins, Vitamin C, Vitamin E, NAC, milk thistle are all really excellent options. But the key thing is is to to just be wise, be smart, don’t overindulge. We can see the long lasting impact in that negative way and who wants to have a acetaldehyde building up in their system? I certainly don’t. When we understand what acetaldehyde is actually doing and the harmful effect that it has within our system, we don’t want to be the the cause of that. If we know how we can make our body make acetaldehyde is through drinking, we should probably not be doing that. So this is that highly reactive compound has a, you know, very detrimental effects. And as I mentioned, most people the way that they feel the acetaldehyde is through kind of those known factors with the with the hangover, but definitely just be be smart. If you’re going to be taking an alcohol, make sure you have the right nutrients on board. Have your green tea to help combat that acetaldehyde and those key vitamins and minerals, as well as your fatty acids, very important.† [00:15:05]
[00:15:06] So I want to thank you so much for tuning in to the InViteⓇ Health podcast. Remember, you can find all of our episodes for free wherever you listen to podcasts or by visiting invitehealth.com/podcast. Now, do make sure that you subscribe and you leave us a review. You can follow us on Facebook, Twitter and Instagram, and we will see you next time for another episode of the InViteⓇ Health podcast.† [00:15:06]
*Exit music*
Immune System, Part 4: Diet and Supplements – InVite Health Podcast, Episode 494
In this episode of the InVite Health Podcast, Amanda Williams, MPH concludes her series on the workings of the immune system. Learn about the important role nutrients such as Vitamin A, Vitamin E and mushroom extract play in your immune defenses.
Immune System, Part 2: The Aging Immune System – InVite Health Podcast, Episode 492
As we age, our bodies experience something called immunosenescence, in which the immune system begins to function less efficiently. This can impact our ability to fend off pathogens, allergens and more.
Immune System, Part 1: The Basics – InVite Health Podcast, Episode 491
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Please see below for a complete transcript of this episode.
Immune System, Part 1: The Basics – InViteⓇ Health Podcast, Episode 491
Hosted by Amanda Williams, MPH
*Intro music*
InViteⓇ Health Podcast Intro: [00:00:04] Welcome to the InViteⓇ Health Podcast, where our degreed healthcare professionals are excited to offer you the most important health and wellness information you need to make informed choices about your health. You can learn more about the products discussed in each of these episodes and all that InViteⓇ Health has to offer at www.invitehealth.com/podcast. First time customers can use promo code PODCAST at checkout for an additional 15% off your first purchase. Let’s get started! [00:00:34]
Amanda Williams, MPH: [00:00:40] Over the past couple of years, you have probably heard and learned more about the immune system than you could have ever imagined. I want to break down the immune system itself and talk about the different aspects and the roles that impact our health, because I think it’s important to have a full foundational understanding. Of course, we’re not going to all become immunologists, but at the end of the day, it’s, it’s key to really understand how it is that our body reacts and responds under certain conditions and when we’re exposed to different pathogens, for example. So I thought I would break this down into multiple podcasts for you so we can look at the relevant actions that our immune system goes through in order to, to keep us healthy. And then what we can be doing on our part to make sure that we age gracefully and that we are doing everything in our power to maintain a healthy lifestyle to boost up our immune defenses.† [00:01:52]
[00:01:53] So I’m Amanda Williams, MD, MPH and the way that I’m going to approach this is I’m going to talk today predominantly on what the immune system actually is. And then in part two, I’m going to look more specifically at what happens just through the aging process. So it’s something actually termed as immunosenescence. I’m going to talk about immunosenescence in part two and then in part three, I want to look at what happens when we have autoimmune issues because everyone has probably heard about autoimmune diseases. And it’s interesting that this can be in a chronic disease or a progressive setting, but it can also be in more of an acute setting, too. So I want to talk about autoimmunity and really look at the difference between passive and active immunization and how the, the body is reacting. So that’ll be in part three. And then in part four, I want to jump into the different nutrients and why it is that certain vitamins and minerals and other key things like probiotic, colostrum, for example, and why our diet really makes such a difference when it comes to supporting our immune defenses.† [00:03:13]
[00:03:14] But let’s just get right to it. Let’s talk about what exactly the immune system is. And as I mentioned, this can be, you know, very complex when we get into the nitty gritty of immunity and understanding that the immune system itself is basically referring to a collection of different cells and proteins that function to protect us from different foreign antigens, for example, or pathogens, as we oftentimes refer to them. And we know that the main goal of the immune system is to protect our bodies against infection and disease. Now, it’s an integrated system of different cells and tissues and organs that all have these important specialized roles in defending us against these pathogenic microorganisms. So when we think about things like bacteria and viruses, parasites, fungi, for example, but we also know that the immune system is really integral to the way that our cells divide. So even when we think about bad cellular division in the setting of cancer, for example, we know the immune system is a guardian to try to protect ourselves from this.† [00:04:30]
[00:04:31] Now all of these different actions that occur have to happen in this very synergistic effect. And understanding the way that these cells and the immune system is working is essential to this. So we know that there are two major components when we look at our immune system, and this is just kind of broadly speaking. We have our innate immunity and we have our adaptive immunity. So what the innate immunity is is that first line of defense against any type of foreign substance or pathogenic microorganism that our bodies are exposed to, whereas the adaptive, this is, hence the name adaptive, it’s adapting over time. So this is a more delayed immune system response. And it’s key to understand the difference between these two because primarily when we think about the innate immunity, this is when we have this recruitment of these different immune cells to the site of a injury or an infection, so where you have inflammation or an infection.† [00:05:49]
[00:05:50] Now this is driven up through cytokines. Now we know that the cytokines, these are the primary thing that we often think about when we think about inflammation. For example, if you’ve heard me talk about this before on the radio, I talk about, you know, cytokine storms and the release via, you know, COX-1, COX-2, the 5-lox pathway, arachidonic acid. So there’s different ways in which cytokines, leukotrienes, prostaglandins are all released. So when we think about the innate immunity, this is kind of in that, that realm that we are thinking about. We think about the innate immune system as having things such as our skin, the physical barriers of our body to try to keep us protected. When we think about the acidity within the gastric juices, for example. These are all ways that we can look at the innate immune system. It’s that initial response. It’s the skin trying to protect us. It’s the gastric juices trying to kill off anything that we may ingest. So all of these things are very important.† [00:07:06]
[00:07:07] Now, seeing the way that the innate immune system is working, this is what really gives us that initial response to any type. So say you get, you know, exposed to a cold, a rhinovirus, for example. It is that innate immunity that drives all of this up. When we think about our macrophages, when we think about neutrophils, these are very, very important immune cells that help to digest any of those invading microorganisms. And that process is actually called phagocytosis. So, like I said, the immune system itself… Very complicated. I love it. I think it’s one of the most interesting forms of really understanding science and studying the human body. And the more that we’re learning now about the immune system, it’s just so impressive. So, so we have the innate immune system, and we know that through this innate immunity, we are able to stave off a lot of the initial foreign pathogens. So this is a quick, rapid response is what we consider the innate. It’s an immediate.† [00:08:34]
[00:08:35] And then we have that delayed. So that’s the adaptive immune system. Now this is that next level of defense. And what we know through the adaptive immune system, being that this is delayed, that this is where our antibody-mediated immunity or our cell-mediated immunity comes into play. So this is when we think about our B cells, our helper T cells, our cytotoxic T cells. All of these fall into that category of the adaptive or the delayed immune response. We also consider this to be acquired immunity. So it’s the second line of defense. This can take several days. This can take weeks to fully develop. It really depends on what that actual exposure to a specific antigen is, that’s whatever is invading the body is what is going to determine the length of time for the acquired immunity to kind of kick in.† [00:09:37]
[00:09:38] So all of these things are working synergistically together. Now what’s very interesting about this is that every single part of the immune system, we’re thinking about the immune cells and whether it be innate or we’re thinking adaptive is highly reliant on different macronutrients, micronutrients, which is why if we have nutritional deficiencies, if we are not getting the right nutrients from our diet, this can weaken our immune defenses. Now, oftentimes we don’t talk about this enough. We just automatically turn towards, you know, OK, you have a bacterial infection. We’re going to give you antibiotic. And of course, that’s going to be the primary line of treatment. But the key thing is, is how do we stop that from even beginning in the first place?† [00:10:30]
[00:10:30] Now the way that we do that is by strengthening up our immune system. Having a good, healthy gut. This is so integral that to understand that 70% of our immune system is located within the intestines. So if we have chronic inflammation that’s occurring within our GI tract, this is going to compromise the integrity of that mucosal barrier, which makes us more vulnerable to all sorts of infections. So whether we’re thinking about a GI infection specifically or if we’re looking at a respiratory illness because at the end of the day, it is that driving force coming from our intestines that allows us to have this ability to drive away the potential negative effect of different pathogenic agents.† [00:11:37]
[00:11:39] Now we know that the micronutrients really come into play here when we’re thinking about all those B-vitamins. When we think about Vitamin A, Vitamin E. Most of the time when people think of their immune system, they think of zinc and they think of Vitamin C. But we have to have all of these different components. We have to have those dietary fatty acids, those omega-3 fatty acids. These are certainly integral to our immune defenses, both innate and adaptive. So our macronutrients, our micronutrients, incredibly important, and we can start to look at how each individual vitamin and mineral and fatty acid is actually working, how they’re helping to activate different genes.† [00:12:31]
[00:12:32] For example, Vitamin A is a key one to to look at this when we think about our generation of antibody responses to a specific antigen. Vitamin A is really key to this. So when we think about our adaptive immune system, Vitamin A now… Well, I guess we oftentimes focus so much on Vitamin C, but Vitamin A is very important for this, so not to go too heavy into each individual vitamin and mineral… We know Vitamin D clearly much more than just for bone health. We have to understand how Vitamin D is integral to the immune system response and the transcription of multiple different genes in the body that help with the activation of both the innate and the adaptive immune system responses. And then, of course, when we look at something like Vitamin C, we know that Vitamin C definitely is working along that pathway of both the innate and the adaptive. So a lot of different moving parts and all of these have to be working efficiently in order for our body to be able to react and respond accordingly to anything that may be trying to invade us or to attack us.† [00:14:00]
[00:14:01] Now, to look more specifically at the different defense barriers that we have in the system… I had mentioned the physical barriers, thinking about the skin, thinking about our gastric juices, but we also have to think about the, you know, temperature regulation in the body. So we have, you know, pH, so the acidity of the body. We think about the temperature of the body. This is why when we get sick, oftentimes the body will start to heat up. So that fever response is to try to naturally kill off… So while a fever is never fun, that’s the body’s way through that innate immune system. So that’s a perfect example of the innate immune system saying, “Hey, something bad has happened. We need to cook this thing.” So this is just an example of those different defensive barriers that our wonderful innate immune response is actually doing for us.† [00:15:08]
[00:15:09] And then looking further down the road when we get into that delayed immune response, we’re looking at the adaptive. This is where the science gets really very interesting because now we’re dealing with these antibodies, we’re dealing with B cells, we’re dealing with T cells. We have these MHC complexes, so this is the major histocompatible complexes. So this is all very, very detailed and it just shows why when we think about different illnesses, whether it’s a virus, whether we’re thinking about, you know, COVID, whether we’re thinking about influenza, whether we’re thinking about Staphylococcus aureus or, you know, Bacillus cereus infections in the body that so many different moving parts are working to keep us healthy. And it really is. It’s so incredibly impressive to think that we are designed this way, that we have these different immunoglobulins that all have these specific purposes. You know, we have IgE, which we know helps with the response within mast cells and histamine. We have IgA, which releases secretory IgA, for example. So we have all of these different immunoglobulins. You can look say, for example, if you had an exposure to, let’s just say, hepatitis, this is one of the ways that they track, is they look for the immunoglobulin response because remember, this is that delayed response. So I get incredibly excited about this because when it comes to immunopathology, I find it so interesting just to see how this simple little cell in the body can be doing all of these many different functions to communicate with this other simple little cell in the body to make sure that we can still exist, that a particular virus or parasite or bacteria isn’t getting into our system and taking us over.† [00:17:22]
[00:17:23] But it’s not just limited, as I mentioned, to to these different pathogens. You know, we can think about chronic inflammation. We can look at the autoimmune component and I’m going to talk about that in another podcast, talking about what is autoimmunity and why does this occur? And what triggers that? So all of these things are so interesting to, to study and to really have a good foundational understanding of. So seeing how much research as far back as probably the last two decades is really focused in on the microbiota. So understanding how the microbiome, those trillions of bacteria that inhabit our bodies, how those are actually working to communicate with our immune cells to help to keep us healthy. And so that’s why if you have an unhealthy gut, you are basically weakening your immune system. And I’m also going to talk about the immune system in aging and in that setting of immunosenescence and why that matters, why we have to make sure that we’re taking in the right nutrients, that we’re doing the right things when it comes to our lifestyle to enhance our body’s ability to fend off any of these potential problems that can certainly arise.† [00:18:52]
[00:18:53] So at the end of the day, we know that we have this immediate response called the innate immunity, and then we have this delayed response that’s called adaptive immunity. We know that within that, we have the requirement of all of these different vitamins and minerals and fatty acids that play an integral role into the way both the innate and the adaptive immune system are working on our behalf. So while immunology in and of itself and immunopathology and understanding all of these different things is just its own field of medicine. So we’re not all trying to be immunologists today, but what we do want to understand is the complexity of the human immune system and why we should not just take it for granted that, you know, if we catch a cold, no big deal, because oftentimes it is no big deal. The immune system can respond. But if we’re doing things to make our immune system weaker, then it is a big deal because we want to be able to respond in the most appropriate and efficient way possible. So understanding the immune system is key to understanding what we can be doing moving forward throughout our lives to make sure that our immune system is not going through this weakening process that is brought on by ourselves.† [00:20:33]
[00:20:34] So I’m going to talk in the next podcast about the aging immune system, and specifically it is called immunosenescence. I’m going to talk about immunosenescence, what that means to our overall immune defenses, what we can do when it comes to restoring that and maintaining a more favorable immune defense mechanism. So there’s a lot to the immune system. I can only cover so much when it comes to really getting into the science behind it because it is, I said, it’s its own field of medicine and research, and it takes years and years to really fully understand the interrelation between how these different cells and how these different micro and macronutrients are all working synergistically together.† [00:21:32]
[00:21:33] So that is all that I have for you for today. Do make sure that you tune in to part two where I will talk about immunosenescence and the aging immune system. I want to thank you so much for your continued support of InViteⓇ Health. And remember, you can find all of our episodes for free wherever you listen to podcasts or by visiting invitehealth.com/podcast. Now, do make sure that you subscribe and you leave us a review. You can follow us on Facebook, Twitter and Instagram @invitehealth and we will see you next time for another episode of the InViteⓇ Health Podcast.† [00:21:33]
*Exit music*