Studies Show D-Mannose Helps Protect Against Urinary Tract Infections – Invite Health Podcast, Episode 169

Studies Show D-Mannose Helps Protect Against Urinary Tract Infections – Invite Health Podcast, Episode 169

Invite Health Podcast, Episode hosted by Jerry Hickey. Ph

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Women are more prone to urinary tract infections than men. Eventually, 1 in 5 women will develop a Urinary Tract Infection. They’re very common.


A urinary tract infection (UTI) is an infection in any part of the urinary system. It could be your kidneys, ureters, bladder and urethra. However, most of the infections in the urinary tract involve the lower urinary tract — just the bladder and the urethra. The most common cause of a UTI is a bacterium that normally lives in your intestinal tract called E. coli (Escherichia coli). Other bacteria can also cause a UTI, but E. coli is the most common. If you don’t treat the infection, it usually doesn’t get better, and if it reaches the kidneys, it can cause a problem.

Women are more prone to UTIs because their urethra is shorter than a man’s, so it takes less time for bacteria to reach their bladder. This makes it is easier for bacteria to reach the bladder and cause an infection. Some women suffer frequently with UTIs.


  • Drink plenty of liquids, especially water.Drinking water helps dilute your urine, ensuring that you’ll urinate more frequently and thus flush out bacteria with a stronger stream of urine.
  • Drink cranberry juice. Cranberries are loaded with polyphenols. They make the urinary tract more slippery, so it’s hard for the bacterium to attach to your urinary tract. This makes it easier to flush the bacteria out of your body when you urinate.
  • Wipe from front to back. Doing so after urinating and after a bowel movement helps prevent bacteria in the anal region from spreading to the vagina and urethra. It’s an important thing because that’s how the E. coli commonly infects women.
  • After intercourse, empty your bladder as soon as possible. Drink a full glass of water to help flush out the bacteria, because you can get a urinary tract infection during intercourse.
  • Avoid potentially irritating feminine products. Some feminine products are very irritating, like deodorant sprays and douches and powders, which can irritate the urethra and cause inflammation in the area.

In addition to the tips above, here’s what I recommend to women who contact me for advice:

  • Cranberry capsules may work better than cranberry juice, since most juices contain a lot of added sugar. Capsules still deliver polyphenols to your body without the sugar.†
  • Hibiscus Tea tastes delicious and has been known to cleanse the urinary tract. You can mix cranberry or white or green tea with it.†
  • Probiotic Bacteria containing certain strains of Lactobacilli start to reach the urinary tract within a week of starting a supplement, helping to prevent future UTIs, as well as vaginal yeast infections.†
  • D-Mannose is a sugar we naturally make in our body. To infect you, bacteria have to stick onto the wall of your urethra. Taking a supplement of D-Mannose makes the urinary tract wall slippery and prevents certain bacteria from sticking to the walls of the urinary tract. When you urinate, the pressure of the urine flushes out the bacteria helping to prevent an infection. Research shows that taking d-mannose might reduce symptoms of UTIs, such as burning and increased urination. Also, taking D-mannose powder after a UTI often prevents them from reoccurring.†

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Clinical Studies on D-Mannose for UTIs

The American Journal of Obstetrics and Gynecology shared a study from August 2020, done by The University of Pittsburgh Department of Obstetrics and Gynecology and Reproductive Sciences and Washington University School of Medicine Department of Obstetrics and Gynecology and Division of Female Pelvic Medicine. They performed a systemic review, sorting through all available data on d-mannose to determine if it had any effect on preventing future urinary tract infections. Through their research, they found that the risk of future UTIs decreased by 77% when on d-mannose, whereas antibiotics only decreased the risk by 61%. They said, “D-mannose appears protective for recurrent urinary tract infections versus placebo with possibly similar effectiveness as antibiotics.” In other words, the d-mannose works and that’s preventing a future urinary tract infection.

The journal Climacteric shared a study from April 23, 2020, done by the University of Pisa’s Department of Obstetrics and Gynecology and the University of Madinah and Jos (10:04) They worked with 40 post-menopausal women who were undergoing prolapse surgery for bulging urinary bladders. The women were split into two groups: one which took a d-mannose with cranberry supplement twice a day for two weeks and another which took a placebo at the same frequency. This was to test to see if the d-mannose would prevent complications like UTIs and cystitis. What they found was the women on the d-mannose and the cranberry did significantly better. They had fewer complications from the surgery. The lower urinary tract symptoms connected with this surgery after menopause was really helped by combining d-mannose and cranberry.

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The World Journal of Urology shared a study of 308 women who had severe UTIs, which were also recurring. The women were split into three groups. One group went on d-mannose for six months, another on a placebo, and a third on a powerful antibiotic called nitrofurantoin, which is commonly used to prevent and treat UTIs. The women on the d-mannose and nitrofurantoin, in comparison to the women who received placebo, experienced far fewer UTI episodes over the six month period. The women on d-mannose had fewer infections than the women on the antibiotic. It was actually more protective than the antibiotic.

The journal Minerva Gynecologia shared a study done at The University of Siena. They looked at how, as women age, it affects their urinary tract and it makes them more susceptible to urinary tract infections. With reduced estrogen after menopause, cystitis becomes pretty common. They also develop bladder inflammation. So what they did was they gave them d-mannose, 150 women age 40-50 suffering with recurring cystitis with or without bacteria. They found that 92% of the women on d-mannose saw improvement in their urinary tract symptoms and UTIs.

The University of Sapienza in Rome’s Department of Gynecology-Obstetrics and Urology, did a study on women with current UTIs, which was shared in the European Review for Medical and Pharmacological Sciences. They found that d-mannose helps you get over a UTI and that it strongly prevented future infections. With d-mannose, only 4.5% of women developed future UTIs. Without d-mannose, a third of them developed future UTIs.

Thank you for tuning in to the Invite Health Podcast. You can find all of our episodes for free wherever you listen to podcasts or by visiting Make sure you subscribe and leave us a review! Follow us on Facebook, Twitter and Instagram at Invite Health today. We’ll see you next time on another episode of the Invite Health Podcast.

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