Written by: Claire Arcidiacono, ND For further questions or concerns email me at firstname.lastname@example.org† Understanding the anatomy of joints is the key to understanding joint health. To start with joints can be described as movable or fixed. Fixed joints are those that don’t move. These include …
In Episode 32, Jerry Hickey, Ph. discusses how the herbs Turmeric and Boswellia can enhance joint health and comfort. Here is the information you need to walk in rhythm!
Invite Health Podcast, Episode hosted by Jerry Hickey. Ph
I’m getting a bit older, and although I am not worried about dementia, I do like to use nutrients that protect my brain. Turns out, both herbs also protect the brain during the aging process and have been shown to improve day-to-day memory.
What is Turmeric?
You have probably heard of Curcumin, many companies use this as the headliner in their joint health formulas. Sadly, Curcumin is only one ingredient out of 235 different constituents so far discovered in Turmeric and curcumin makes up 2% to 5% of the plant ingredient. In fact, if you don’t make the Curcumin more water soluble it will be very poorly absorbed.
Besides, research out of Baylor University Medical Center in Dallas, Texas shows you need the complete plant, and it should be safely modified to be well absorbed to obtain it’s true level of benefit. This is why Baylor has chosen BioCurcumin for their human clinical research.
Turmeric containing curcuminoids is usually available ground, as a fine, bright-yellow powder. It is a major constituent in curry, giving it both its color and flavor. The medicinal history of turmeric is at least 2500 years old. Ayurveda, Unani, Siddha and Chinese medicine recommend turmeric for a large number of disorders and diseases. Ayurvedic medicine was the first scientific form of medicine. In it, the effects of plants and therapies for differing conditions were observed and systematized.†
But Turmeric is poorly absorbed. BioCurcumin is extremely well absorbed and research shows it readily enters our human brain, offering multiple benefits according to a number of human clinical trials. Interestingly Curcumin and Turmeric only last for several hours in the human body.
What is BioCurcumin?
BioCurcumin contains the whole plant. In fact, 95% of it is the active ingredients and this matters. Most supplements from Turmeric only offer curcumin. There are a number of other related ingredients such as demethoxycurcumin and bisdemethoxycurcumin that are actually more beneficial than the often cited Curcumin itself.
BioCurcumin offers the full spectrum of these curcuminoids. Additionally, it supplies the Turmeric-essential oils, including aromatic-Turmerone which are very important for brain health and memory support; Curcumin products lack these important constituents.
BioCurcumin is grown organically, and in fact is grown 100% using solar power in soil that has never been exposed to pesticides. It consists of the all the ingredients found in Turmeric and is safely extracted without the use of toxic solvents. When other companies use cheap solvents to extract their Curcumin, these can never be totally removed from the finished product and this is why InVite® never uses an ingredient obtained by the use of toxic solvents.
In BioCurcumin, the powerful polyphenolic Curcuminoids and the terpene essential oils are present and they strongly combine to reduce joint discomfort and inflammation in your knee but they also work together for brain health; you need the combination of all of these ingredients and not just curcumin.†
Benefits of BioCurcumin
5-Loxin is an ingredient isolated from the herb Frankincense, the herb is also known as Boswellia serrata; it inhibits the 5-Lipoxygenase pathway, therefore the name 5-Loxin. In animal studies the 5-Lipoxygenase pathway is involved with brain inflammation, poor brain health, and worsening of memory. The herbal ingredient 5-Loxin inhibits the 5-Lipoxygenase pathway of inflammation.†
In a recent study published in the journal Archives of Gerontology and Geriatrics combining Boswellia serrata with the herb Lemon Balm improved various aspects of memory in a day-to day manner in a group of older adults. 5-Loxin is obtained from the resin extract of the frankincense plant and it is very safe and works very well for joint discomfort and works very quickly to offer relief and as it turns out, it also addresses inflammation in the human brain. 5-Loxin is superior to typical Boswellia serrata extracts.†
In a clinical study of children being treated with radiation at the University of Freiburg Hospital in Germany, adding the herb Boswellia serrata to the powerful steroidal anti-inflammatory drug dexamethasone strongly improved the number of children with a reduction of swelling caused by radiation related in their brains of children and it was very safe.
Turmeric, if modified to be well absorbed, has many studies demonstrating its impact on our mood and memory. Five different studies show BioCurcumin improves mood if used alone or added to prescription antidepressant drugs such as fluoxetine and once again it was very safe to use in these vulnerable patients.†
Interestingly, the way BioCurcumin achieves this mood improvement may be related to the way it improves memory and it has to do with a healing factor in the brain called BDNF. BDNF is the abbreviation for brain derived neurotrophic factor. It is like Miracle Grow for the brain; brain fertilizer. Young people release a lot of BDNF every day and this triggers the formation of about 700 new memory cells in the hippocampus every day; the hippocampus is largely where memory takes place. This adds up in a very good way – brain cells die off all of the time in a process called apoptosis to remove senescent cells; they must be replaced and BDNF triggers the replacement of memory cells. In this way you keep the brain young and active and by the time you’re fifty you have replaced all of your original memory cells with these newly formed neurons.†
Ten years ago we didn’t know you could create new memory cells.
– Jerry Hickey, Ph.
Older people release a lot less BDNF therefore they are replacing fewer and fewer senescent memory cells every day and this adds up in a bad way leading to memory loss, an inability to learn, and in some, brain shrinkage.
In a recent study published in the journal Nutrition Research scientists performed a systematic review of the literature. They found four high quality studies showing that Turmeric supplementation significantly increased the level of BDNF in the serum of study subjects. This leads to the formation of new hippocampal memory cells. Creating new memory cells is a way that antidepressant medication also improves depression so this could be at least one of the ways that BioCurcumin is good for both depression and good for day-to-day memory enhancement.†
In another recent study of healthy older people aged between 50 to 80 from Swinburne University in Australia, giving them a very well absorbed curcumin for 12 weeks significantly improved working memory and reduced brain fatigue compared to taking placebo. Stressful mood components such as anger, tension, and confusion also improved in the Curcumin group.†
Still additional recent research from the University of California, Los Angeles (UCLA) Longevity Center giving enhanced absorption curcumin twice daily enhanced memory and mood in older people with mild, age related memory loss over the 18 month study period. It showed great promise for alleviating cognitive decline by improving memory by 28%.
Very importantly, a subgroup of 30 of these subjects at UCLA also had PET scans of their brains to assess the level of beta-amyloid plaque formation and the tangling and extremely destructive tauopathies that kill bundles of nerves in regions of the brain involved with memory. Analysis of the PET scans connected cognitive benefits such as improved memory with a decrease in tangle and plaque accumulation in these brain regions responsible for mood and memory. The UCLA study is published in The American Journal of Geriatric Psychiatry.
Importantly a review of six human clinical trials by Chinese neurologists giving well absorbed Turmeric/Curcumin to older subjects significantly improved memory and it was as safe as placebo, the same level of safety seen in all of these other studies.†
Well absorbed BioCurcumin improves working memory very rapidly, almost immediately.
In a study published in the Journal of Psychopharmacology using BioCurcumin in elderly subjects aged 60 to 85…giving the Turmeric product for a month saw an improvement in brain function very quickly. An hour after taking BioCurcumin, working memory and sustained attention had already improved and the elderly were less fatigued after performing a mental challenge compared to those on placebo.
Unfortunately research shows that giving regular Turmeric as a supplement will not reach the brain; not enough is absorbed into the blood stream from the digestive tract to make a difference. It has to be a well absorbed Turmeric such as BioCurcumin to truly reach the brain in a concentration high enough to protect and improve memory and mood. With the addition of 5-Loxin we are helping to restore protective antioxidant activity to the aging brain. Antioxidant protection strongly declines in the brain in our late fifties. Free radicals can then harm and destroy memory cells. It is very important for older adults to utilize antioxidants that offer valid protection for their brain.†
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Photo by Akhil Chandran on Unsplash Turmeric is a fine, bright-yellow spice that been used in Indian culture for thousands of years for both its healing properties and cosmetic benefits. It is available as a spice, has been included as a potent ingredient in numerous …
Turmeric is the herb that gives curry its major culinary characteristics. The turmeric root supplies many constituents related to ongoing good health; curcuminoids and essential oils often referred to generically as curcumin. Unfortunately these constituents are difficult to absorb. BioCurcumin is an extremely well absorbed …
Jerry Hickey is a pharmacist and radio personality and fills the esteemed role of Scientific Director and President of Invite Health. He has spent his professional life analyzing nutritional information and medical studies with the aim of creating the highest quality and most natural nutraceuticals for user’s maximum health benefits. Here, Jerry speaks about the benefits of Curcumin…
There are thousands of studies and hundreds of human clinical trials on curcumin. Here’s a study on curcumin published in the American Journal of Cardiology. They took people that were having CABG, or coronary artery bypass grafting which is a serious operation. It includes taking a blood vessel from a different part of the body or from some other animal and putting it in your body to improve the blood flow inside of your heart. Researchers took 121 patients that were having a CABG and gave them a curcumin, like Bio-Curcumin, or an inactive placebo, starting three days before and continuing for five days after the surgery. Now, the reason they did this is because people who go for CABG surgery have a risk of suffering from a heart attack during or after surgery. Now, these heart attacks usually are not fatal, especially since you have cardiac nurses and cardiologist medical doctors surrounding you while performing the surgery. The problem is that any heart attack can cause damage to your heart. So, 121 people who were going for a CABG, about half of them were given Bio-Curcumin starting three days before and continuing for five days after the surgery. It cut down the risk of a heart attack related to the surgery by 65%. Thirty percent of people not on curcumin had heart attacks, which sounds pretty high. Only 13% on curcumin had a heart attack. So, it cut the incidents of heart attack and the risk of heart attack dramatically in people who were having heart surgery this may be because heart attacks can be triggered by inflammation during the surgery and exposure to free radicals, which occurs when blood flow to the heart stops. When you consume curcumin, it lowers inflammation in the body.
Smokers are prone to colon cancer. When they gave smokers curcumin, it reduced the number of precancerous cells in their colon by 40% within the first 30 days. Smokers develop a lot of cancers, and one of the cancers is colon cancer. The reason for that is due to the cells that release mucus in the colon and the intestines which protects it from bacteria, solvents and toxins. These can become inflamed from cigarette smoke, making it precancerous and then cancerous. So, when they gave smokers curcumin, within 30 days, they had 40% fewer precancerous cells.
One of the current studies going on with curcumin right now is comparing a certain type called Bio-Curcumin to Prozac to see if it’s as effective for depression. They’re giving patients curcumin, Prozac or curcumin with Prozac and, of course, some of the patients were taking a placebo. There’s another curcumin study from the Jewish General Hospital in Montreal, Quebec, and they’re adding it to chemotherapy for lung cancer patients to see if it improves their chances of survival.
One of the ingredients is from the frankincense plant, it’s called 5-Loxin, named after the pathway that it inhibits in joint discomfort. There are two distinct pathways that cause inflammatory response throughout the body. Like with lung inflammation or skin inflammation and itching in the colon, some of those immune-derived inflammatory responses are a problem for people. The absorbable form of Turmeric (Biocurcumin) and Boswellia (5-loxin), when combined, inhibit the COX-2 enzyme, proven through studies at Baylor College. Traditionally, that’s how they help joint discomfort. The other, the 5-Loxin, inhibits a really nasty enzyme called the 5-Lox enzyme that makes a body sore and uncomfortable.
There have been many human clinical trials on both of these ingredients; they’re both well-absorbed, and safe. During a 90-day clinical trial on 75 patients with very sore knees, a study found that within the first week, 5-Loxin was improving their quality of life; They had more mobility, their knees were more flexible, they could bend them and walk up the stairs more comfortably and pain was decreased.
Bio-Curcumin & 5-Loxin
The two herbs we discussed both work differently, complementing each other’s benefits. Just one herb showed a 53 percent improvement in pain scores, according to the medical doctors and joint specialists, a 63 percent improvement in stiffness scores, a 50 percent improvement in the ability to walk and carry out the activities of daily living. This is all according to the clinician. When they asked the patients, the patients actually rated it as a 70 percent improvement. That’s just from one ingredient!