Nutrition. Vitamins. You.
If you’re looking to build and maintain muscle health, it’s important to make sure you are getting the proper nutrients. Learn more about the nutrients you need from Melissa Bistricer, RDN.
If you spend your days staring at phone, TV or computer screens, you need to know about what supplements can benefit your eye health, and your eye doctor should, too.
lupus
Subscribe Today!
Please see below for a complete transcript of this episode.
Hosted by Amanda Williams, MPH
*Intro music*
InViteⓇ Health Podcast Intro: Welcome to the InViteⓇ Health Podcast, where our degreed healthcare professionals are excited to offer you the most important health and wellness information you need to make informed choices about your health. You can learn more about the products discussed in each of these episodes and all that InViteⓇ Health has to offer at www.invitehealth.com/podcast. First time customers can use promo code PODCAST at checkout for an additional 15% off your first purchase. Let’s get started!
*Intro music*
Amanda Williams, MPH:
[00:00:40] When it comes to our immune system, sometimes things can go haywire, and today I want to talk about a autoimmune condition that commonly affects women. So 9 out of 10 people who are diagnosed with lupus are women, and we know that just according to statistics, we recognize that there’s roughly about one and a half million Americans who have a form of lupus. Certainly, men can be impacted by this. Children, teenagers. But for the most part, we find that a good 90% are going to be women. Between usually the ages of 20 and 40 is when the initial diagnosis occurs with lupus. So I want to talk a little bit about what exactly lupus is and what you can be doing if you yourself have been diagnosed with this, or if you happen to have a friend, a family member, a coworker who has been diagnosed with lupus.† [00:01:43]
[00:01:43] So I’m Amanda Williams, MD, MPH, Scientific Director here at InViteⓇ Health and lupus is a incredibly detrimental systemic disease. Whenever our immune system decides that it’s going to rear its ugly head and create havoc for us, that is a big problem. And there are so many different autoimmune conditions. You can look at things such as lupus, we can look at rheumatoid arthritis, we can look at diabetes. We know that there are many different ways to which our immune system can go from being a very protective thing in our, in our body to something that can be very destructive.† [00:02:30]
[00:02:31] Now we know that lupus has a common driving force, and that is inflammation. Now when you look at lupus, this is… We usually just shorten it to lupus, but we’re talking about systemic lupus erythematosus and SLE. Now we know that when it comes to SLE, hence just lupus, we’re dealing generally with multiple areas in the body. So the skin, kidneys, heart, the entire cardiovascular system, the nervous system, connective tissue, the skeletal muscular system, as well as other areas that can be impacted because of the significant inflammation that occurs. So when people have lupus, oftentimes the way that they present and many of the complications is that there are multiple organ systems that have been impacted by this. So this puts someone with lupus at a higher risk of having a heart attack, having diabetes, having chronic kidney disease, bone loss, osteoporosis, as well as different blood disorders.† [00:03:44]
PAINFUL KIDNEY STONES – INVITE HEALTH PODCAST, EPISODE 44. Listen Now>>
[00:03:46] We can see that there are certain areas in the country to which lupus diagnosis can be at a higher rate. So we know that there is a Vitamin D connection to lupus. So you’re going to see higher rates of lupus being diagnosed throughout the Midwest, as well as the Northeast than you do in other parts of the country, including the the west coast of the country, as well as the Southeast. So we know that Vitamin D, which remember, Vitamin D is critical to our immune system. We know that Vitamin D is definitely playing a significant role. We recognize that not only is it geographically driven, but it is also very much so race driven. And we are going to see higher rates of lupus in those who are African-American, Asian-American, Native American as well as Latina women. You see this in a much greater rate, the incidence in these women, much more than you do in Caucasians. This is an area where I think it’s commonly overlooked as a public health issue, and there are so many things that should be done and can be done to improve upon the health outcomes for anyone who is diagnosed with lupus and many of the signs and symptoms of lupus can vary from one person to the next.† [00:05:18]
[00:05:19] Now, the actual diagnosis is going to come down to serum blood levels of those autoantibodies. So looking at the antibodies in the blood. But we know that sometimes people or people present with just really extreme fatigue. They may have painful, swollen joints, muscle pain. Many times people know the famous butterfly rash, but it is a rash across the cheeks. Now, that doesn’t mean that every person who has lupus will develop that because there are different types of lupus and the different systems or organs to which lupus attacks can vary from one person to the next. For some people, they can experience it with pain in their chest when breathing. So there’s many different ways. Headaches is another one that sometimes people will present with, you know, swollen joints and headaches, and it’s like what is actually happening? And then they do the serum tests and then they can see, yes, indeed, this is a case of lupus.† [00:06:27]
[00:06:28] Now, conventional treatment for lupus is very… It can be very beneficial, but it can also come with a whole host of different side effects. So many of the anti-malarial drugs, which are antiparasitic drugs, are oftentimes prescribed to those who have lupus. Now, those come with a whole host of different side effects, including significant damage that can occur within the liver. We can definitely look at the overuse of anti-inflammatory drugs, the NSAIDs, so chronic use of NSAIDs in someone who has lupus can lead to damaging effects once again when it comes to the health of the kidneys, as well as the liver, just depending upon which NSAID someone is using.† [00:07:19]
[00:07:20] So what can be beneficial in terms of what someone with lupus can do? We know that looking at the diet, making sure that we’re not adding insult to injury by having a pro-inflammatory diet foods that are going to drive up even more inflammation, so you want to have an anti-inflammatory diet. Fruits and vegetables. High antioxidant foods. Healthy fats. Things that are going to help to lower your inflammatory burden. Understanding how much stress plays a role into this. Remember, stress will drive inflammation as well. So management of stress, whether this is, you know, finding ways to do meditation or yoga or exercise, all of these make a big difference.† [00:08:08]
[00:08:10] And then we have to look at different natural interventions. Knowing that Vitamin D is directly linked to this… If you look at people who have lupus and you test their serum Vitamin D levels, you are likely to find significant insufficiency and even deficient Vitamin D levels. But we can also look at how Vitamin E, you know, inadequate Vitamin E intake can be another driving factor for this inflammation that drives up in the system. We can look at how omega-3s, so by incorporating in fish oil or krill oil, how beneficial this can be for easing inflammation. Of course, we can look at hormonal pathways, and they’ve been able to show… There’s a very important adrenal hormone known as DHEA, and low levels of DHEA have been observed in patients who have lupus, as well as other inflammatory diseases. So oftentimes you will find doctors who will prescribe DHEA to help to improve upon the health of those who have these inflammatory autoimmune conditions.† [00:09:27]
LOW DHEA LEVELS MAY EXPLAIN CHRONIC INFLAMMATION – INVITE HEALTH PODCAST, EPISODE 229. Listen Now>>
[00:09:28] So lupus itself, we know it’s a systemic autoimmune disease driven by inflammation, so the immune system is attacking tissues in the body. We know that when it comes to which system is going to be affected most, this is going to vary from one person to the next. We know that there are different types of lupus. You have SLE, which is systemic lupus, meaning that this is affecting multiple systems in the body. You have discoid lupus. Now this is… Generally speaking, discoid lupus is only affecting the skin. Then you have drug-induced lupus. So this is when you were on a particular medication that then triggers an autoimmune response. There are different drugs that are frequently associated with creating this drug-induced lupus. So this can be many of the cardiovascular drugs antiarrhythmic drugs, hydralazine, which is a blood pressure lowering drug. So we can see how it is that lupus can present in different ways for different people.† [00:10:42]
[00:10:43] But at the end of the day, what we need to do is make sure that we are doing everything in our power to lower that inflammatory burden in the system. So we want to make sure that when it comes to the dietary intake that you are adhering to an anti-inflammatory diet so that Mediterranean diet really comes into play. We know that we don’t want to have to continuously turn to the anti-malarial drugs and the high dose NSAIDs in order to try to regulate this. So we want to try and help our immune system out ourselves by giving the immune system adequate nutrients, key vitamins and minerals. Those omega-3 fatty acids that we know are so key. So Vitamin D is going to be the number one thing that you look at. We know that when it comes to lupus, deficiency of Vitamin D is going to be incredibly high. And if someone with lupus doesn’t have Vitamin D deficiency, it’s pretty much guarantee that they will have insufficiency, meaning low levels, but not to the level of complete deficiency. So having your serum 25-hydroxyvitamin D level tested is incredibly important so that you’re supplementing with the right amount of Vitamin D every day to get you back into a healthy range to once again help to regulate the immune system response. Remember, when you’re taking Vitamin D, it’s always advantageous to take magnesium to help with that proper absorption. We want to incorporate in our fish oil or krill oil, or if you want to use the vegetarian option, using flaxseed. I always encourage anyone who has been diagnosed with lupus to incorporate Vitamin E. We know that Vitamin E certainly plays a essential role in terms of stabilizing cellular membranes. So we want to make sure that those immune cells have that support, and we know that Vitamin E certainly can block that autoimmune attack just through that action of stabilizing the cell membrane. They’ve done studies where they’ve shown how Vitamin D supplementation can actually reduce the level of autoantibodies in lupus patients.† [00:13:22]
[00:13:23] We have to look at other herbal extracts. There have been many studies done with curcumin and understanding that the bioactive components those curcuminoids can do a wonderful job in terms of easing that inflammation through targeting and suppressing or lowering different cytokines that are directly linked with lupus. So looking at things like different interleukins and tumor necrosis factor alpha. We can look at the clinical trials where they’ve given curcumin extract to patients with lupus, and they can start to see an improvement across all different markers, including those who have significant impact to their kidneys. Remember, lupus is going to attack multiple organ systems. When it attacks the kidneys and creates kidney disease because of lupus, so you get nephritis, so inflammation within the kidney, they can see how it is that that curcumin can help to stabilize that kidney function. So a lot of different things that we can be looking at. We can look at that hormonal component. And if your DHEA levels are low, then looking at supplementation with DHEA can help to create that balance once again within that adrenal stress response, but at the same time helping to heighten the body’s immune system, so it’s not going into this self-destructive mode. So lupus is something that you definitely want to make sure that if you know someone, if you, you yourself have lupus, that you take action in terms of diet, exercise and proper supplementation to have a better management of this autoimmune condition.† [00:15:21]
[00:15:22] So that’s all that I have for you for today. I want to thank you so much for tuning in to the InViteⓇ Health Podcast. Remember, you can find all of our episodes for free wherever you listen to podcasts or by visiting invitehealth.com/podcast. Now do make sure that you subscribe and you leave us a review. You can follow us on Facebook, Twitter and Instagram @invitehealth and we will see you next time for another episode of the InViteⓇ Health Podcast.† [00:15:22]
*Exit music*
Selenium may be a micro mineral, but it is essential for important functions in the body such as immune defenses, heart health and more.
Although most adults in America have consumed alcohol at some point in their lives, they are often unaware of how this can impact their overall health and wellness.
inflammation
Subscribe Today!
Please see below for a complete transcript of this episode.
Hosted by Amanda Williams, MPH
*Intro music*
InVite Health Podcast Intro: Welcome to the InViteⓇ Health Podcast, where our degreed healthcare professionals are excited to offer you the most important health and wellness information you need to make informed choices about your health. You can learn more about the products discussed in each of these episodes and all that InViteⓇ Health has to offer at www.invitehealth.com/podcast. First time customers can use promo code PODCAST at checkout for an additional 15% off your first purchase. Let’s get started!
*Intro music*
Amanda Williams, MPH:
[00:00:40] Inflammaging part two. So I want to today define what nutrients are incredibly beneficial when it comes to targeting chronic inflammation. So we know that inflammaging, it’s going to be accelerated aging because of chronic inflammation. Not a good thing. So I’m going to talk about the nutrients and why it matters to make sure that we’re addressing that inflammation in the body. So I’m Amanda Williams, MD, MPH, and let’s get right to it.† [00:01:13]
[00:01:13] Let’s talk once again about chronic inflammation and why it is that when we think about the long-lasting impact of inflammation and how we can tie it to cardiovascular disease, to cancer, to diabetes, to chronic kidney disease, to nonalcoholic fatty liver disease, which we certainly see is on the rise here in this country in particular because of our diet of that high processed foods, looking at autoimmune conditions, neurodegenerative disorders, we see this. We know that there is evidence that the risk of developing chronic inflammation is known to obviously persist throughout our lives, but it goes up exponentially as we become adults because of underlying health conditions.† [00:02:08]
[00:02:08] Now what came first, the health condition or the inflammation? That’s always the big question. Well, we know that it’s the inflammation. It is through, say, glycation, for example, we have excess glucose. That glucose, which is now doing damage… The immune system is going to try to respond or react to that, so it drives up the inflammation. So a normal inflammatory response… Except in acute inflammation, we definitely want that. But it’s that chronic inflammation that we know is certainly the big issue. So seeing and understanding the implications of chronic inflammation is certainly majorly problematic.† [00:02:52]
[00:02:53] So let’s think about the outside factors that helped drive that. We can look at physical inactivity, we can look at obesity, we can look at gut dysbiosis, which is obviously going to affect our immune function, which then triggers that inflammatory response. The diet, the Standard American Diet, this is the primary causative reason for chronic inflammation. We can look at stress. If someone is continuously stressed, whether that be emotional or physical stress, this is going to drive inflammation. We can look at inadequate sleep, how that can drive inflammation. We can look at environmental exposures to different chemicals, how that can drive inflammation. And all of these are linked to metabolic syndrome, type two diabetes, cancer, depression, autoimmune conditions, osteoporosis, sarcopenia, which is age-related muscle mass loss. Immunosenescence, I talked about that in the Immune System podcast, so you can always check that out. I have a four-part series on immune health.† [00:04:01]
IMMUNE SYSTEM, PART 2: THE AGING IMMUNE SYSTEM – INVITE HEALTH PODCAST, EPISODE 492. Listen Now>>
[00:04:02] So today, let’s talk about what we can do in the setting of chronic inflammation when it comes to nutrients. Now here’s the interesting fun fact. Oftentimes people think I have inflammation, I need an anti-inflammatory. If you are going out and taking a non-steroidal anti-inflammatory for your chronic inflammation, you are not doing your body any justice. Your ibuprofen is not going to help with that chronic inflammation that’s doing that systemic damage. What we need to do is we need to basically key in on the health of the cells and what those cells need. So we can look at very basic things, magnesium, Vitamin D, Vitamin E, omega-3 fatty acids. These are all key to making sure that, at that cellular level, that the cell can function in a much more efficient way.† [00:04:56]
[00:04:56] We know that magnesium has been associated with lower levels of inflammation. They’ve been able to assess that higher serum magnesium directly correlated to lower C-reactive protein levels, lower tumor necrosis factor alpha levels. And we know that many people have magnesium insufficiency or deficiencies.† [00:05:19]
[00:05:20] We can look at Vitamin D, our hormone vitamin, and see how this plays a role in terms of an anti-inflammatory effect in the body. It does this through the inhibition of NF-kappa beta, which is a master driver or regulator for inflammation in the, in the body. They’ve been able to see how low Vitamin D level was associated with higher levels of C-reactive protein, higher levels of NF-kappa beta.† [00:05:53]
[00:05:53] We can look at the impact of Vitamin E when it comes to inflammation. Most people think of Vitamin E just in terms of its antioxidant properties, but we actually know that Vitamin E has this anti-inflammatory action to it through the inhibition of COX-2. So when we think about the different pathways to which chronic inflammation has driven up, COX-1, COX-2, the lox pathway, the arachidonic component to this, we can see how when people have adequate Vitamin E exposure, that their levels of C-reactive protein, tumor necrosis factor alpha are lower. So through supplementation of Vitamin E, you’re actually helping to support the cellular ability to fend off inflammation.† [00:06:43]
[00:06:47] So all of these basic things, magnesium, Vitamin D, Vitamin E… Omega-3 fatty acids are kind of that go-to when it comes to targeting inflammation. We know that the omega-3 fatty acids with their special unique properties with the resolvins and the protectins can help to target inflammation and help the body when it comes to a better response.† [00:07:17]
[00:07:19] And of course, we can look at many of the other plant-based nutrients that have been shown to be incredibly beneficial when it comes to targeting chronic inflammation, things such as resveratrol, curcumin, those powerful polyphenols that come from green tea, the EGCG. We can see the downregulation of an inflammatory response and the positive impact the body has in the exposure to EGCG coming from green tea. We know that the trans-resveratrol helps to target those inflammatory pathways through cyclooxygenase, tumor necrosis factor alpha, NF-kappa beta. Hence, why resveratrol was always touted as the anti-aging supplement. Well, think about anti-aging, what’s one of the main drivers for aging is inflammation. So technically, we can call resveratrol the inflammaging-targeted nutrient. It’s targeting that inflammation to support healthier aging.† [00:08:30]
[00:08:33] So we have all of these different ways to which we can just take these nutrients in via supplementation, so making sure we’re taking our magnesium, our Vitamin D, our Vitamin E, our omega-3 fatty acids coming from fish oil or krill oil. Adding in nutrients such as resveratrol, the Resveratrol HxⓇ is an excellent choice, powerful amount of that trans-resveratrol. We can look at adding in the Bio-Curcumin 5-Loxin. The combination of those powerful curcuminoid oils along with boswellia extract to target once again those inflammatory pathways. There are many things that can help to potentiate a better immune system response and hence lower inflammation in the body.† [00:09:30]
[00:09:33] Our diet and our exercise certainly make a huge difference as well. So adhering to an anti-inflammatory diet as opposed to a pro-inflammatory diet, which is the Standard American Diet with the high processed foods and the sugar, the bad carbs and the bad fats. Adherence to that Mediterranean Diet is going to help the body with a more normalized inflammatory response. So we’re not walking around like this slow-burning forest fire. So I can go on and on and on with all of the different nutrients that we know target inflammation in the body. You know, cumin extracts or the Black Seed with Rosemary & Cordyceps. Very good choice. We have the InflamMune, which is the green-lipped muscle along with the perilla extract. We have many different formulations that are very specified to targeting inflammation to optimize our health. But even if we just look at the basics and we say, “Let me make sure I’m taking my magnesium, my Vitamin D, my Vitamin E, my omega-3 fatty acids. Let me just start there.” That in and of itself can do so much to combat that chronic inflammation that we know drives so much of the detrimental effects from all of these different health conditions that people generally succumb to when you think about cardiovascular disease and cardiovascular mortality. We want to maintain the health of all systems, and the way to achieve that is through the regulation of inflammation. So we don’t want inflammaging. We want to age gracefully and our key to success in doing this is through targeting inflammation.† [00:11:22]
[00:11:23] So that is all that I have for you for today. I want to thank you so much for tuning in to the InViteⓇ Health Podcast. Remember, you can find all of our episodes for free wherever you listen to podcasts or by visiting invitehealth.com/podcast. Now, do make sure that you subscribe and you leave us a review. You can follow us on Facebook, Twitter and Instagram at @invitehealth and we will see you next time for another episode of the InViteⓇ Health Podcast.† [00:11:23]