Recent Posts

How To Fight Springtime Allergies, Invite Health Podcast, Episode 636

How To Fight Springtime Allergies, Invite Health Podcast, Episode 636

Subscribe Today! Please see below for a complete transcript of this episode. HOW TO FIGHT SPRINGTIME ALLERGIES, INVITEⓇ HEALTH PODCAST, EPISODE 636 Hosted by Amanda Williams, MD, MPH *Intro Music* InViteⓇ Health Podcast Intro: [00:00:04] Welcome to the InViteⓇ Health Podcast where our degreed health 

Mood Matters To Your Health, Nutrients Can Help, Invite Health Podcast, Episode 635

Mood Matters To Your Health, Nutrients Can Help, Invite Health Podcast, Episode 635

Subscribe Today! Please see below for a complete transcript of this episode. MOOD MATTERS TO YOUR HEALTH, NUTRIENTS CAN HELP, INVITEⓇ HEALTH PODCAST, EPISODE 635 Hosted by Amanda Williams, MD, MPH InViteⓇ Health Podcast Intro: [00:00:04] Welcome to the InViteⓇ Health Podcast, where our degreed 

GOUT

GOUT

 

 

Written by Dr.Claire Arcidiacono, ND

For further questions or concerns email me at carcidiacono@invitehealth.com

Last week we finished our conversation about lupus. Today we will be discussing gout. Gout will be the last condition specific blog in this series on joints. What exactly is gout? Basically, gout is a form of inflammatory arthritis in the joints. This arthritis is interesting because it is associated with uric acid build up in the joints. This uric acid causes the joints to become inflamed and this inflammation is what leads to the joint damage and pain. (1) Please see picture for exactly what this looks like. † (2)

 

Symptoms of gout may sound familiar, interestingly gout usually starts in the joint of the big toe. As the condition progresses more and more joints become involved. Like other inflammatory disorders in gout the joints will be red, tender, swollen and even warm to the touch. In addition to joint pain the buildup of uric acid can also cause the buildup of crystals in the kidneys leading to what is known as urate nephropathy. In addition to these symptoms’ gout can also lead to systemic symptoms such as fatigue and even a high fever. † (3)

The symptoms of gout are caused by the buildup of uric acid crystals. Therefore, anything that increases the uric acid levels in the body will increase the risk of developing gout. Diet is a very well-known risk factor for gout. A diet high in alcohol, meat, seafood and sugar can increase the uric acid in the body and thus can increase gout risk. (4) Another well-known diet-based risk factor for gout is a diet that is high in purines which can increase uric acid.  Purines are a part of every cell and break down into uric acid.  Because they are found everywhere it is impossible to eliminate them entirely. It is possible to try and limit the foods that have a very high purine content. (5) These foods include but are not limited to anchovies, shrimp, mushrooms, seaweed and organ meats. (6) Some research has indicated that potatoes as well as chicken can increase the risk of developing gout. (7) As a result of the fact that gout occurs when uric acid builds up anyone that has kidneys that do not excrete the uric acid properly is at a higher risk of developing gout. † (8)

Certain genes have been found to increase the risk of developing gout. Therefore, anyone with a family history of gout may want to reduce their other risk factors for the disease. † (9)

Gout is associated with certain medications as well as certain chronic conditions. For example, diuretics, niacin, aspirin, ACE inhibitors as well as Beta blockers and even some chemotherapy may increase the risk of gout. (10) Interestingly with excessive vitamin D (blood work showing vitamin D over 80) there is an increased risk of gout. (11) A few examples of chronic conditions that are associated with gout include but are not limited to the following: metabolic syndrome, kidney failure, organ transplant recipients, those exposed to lead and those who are obese/overweight. † (12)

Other triggers that can lead to a gout flare up can include rapid changes in the weather. Additionally, trauma, surgery and having sleep apnea increase the risk of gout. † (13)

While having high uric acid on blood work or hyperuricemia is considered to be a classic sign of gout not everyone with gout has this classic sign. In fact, up to 50% of people with gout never develop high uric acid on blood work. (14) In order to diagnose gout uric acid crystals are found in the synovial fluid of the joints. (15) Other conditions that should be ruled out can include but are not limited to pseudo-gout, RA, psoriatic arthritis and rheumatism. † (16)

ICYMI:PSORIATIC ARTHRITIS>>READ NOW!

The goals of working with gout include stopping the acute attack or flare up that is occurring right now and then from there we work on lowering the uric acid. By lowering the uric acid, we can reduce the risk of a flare up in the future. Now I know some people might think that they only need to work on gout during a flare up but it’s important to work to reduce the uric acid levels regardless of flare up status. Each gout “attack” or flare up increases the risk of damaging the joint. This can lead to destruction of the joint surface and even cause the joint to become deformed. Lastly in 30% of those with untreated gout something called tophi can occur. This is basically a buildup of uric acid that most commonly occurs on the ear, olecranon process and the Achilles. † (17) Please see the attached picture (18) †

 

 To help reduce uric acid and thus reduce the risk of gout the following have been found to be helpful:

  1. Low purine diets have been found to help reduce the uric acid and reduce the risk of a gout flare up.† (18)
  2. Potassium deficiency has been found to be associated with gout. Thus, taking potassium and correcting that deficiency can help the gout. † (19) Please see Invite’s Uric Hx
  3. Celery root has been found to reduce the risk of gout flare ups. † (20) Please see Invite’s Uric Hx
  4. Chanca Piedra root has been found in studies to reduce uric acid levels. † (21) Please see Invite’s Uric Hx
  5. Tart cherry has been found to lower uric acid levels and reduce the inflammation found in gout. † (22) Please see Invite’s Beets Hx
  6. Magnesium has been found to lower uric acid build up and help reduce gout flare ups. † (23) Please see Invite’s extensive line of magnesium products.
  7. Turmeric has been found to help with swelling and pain. † (24). Please see Invite’s Biocurcumin, and Curcumin blend.†

Next week we will be discussing how to heal from surgical based interventions. †

REFERENCES

  1. Abhishek, A; Roddy, E; Doherty, M (February 2017). “Gout – a guide for the general and acute physicians”. Clinical Medicine. 17 (1): 54–59. doi:7861/clinmedicine.17-1-54. PMC 6297580. PMID 28148582.
  2. https://www.bouldermedicalcenter.com/about-gout-causes-symptoms-and-treatment/
  3. Dalbeth, N; Merriman, TR; Stamp, LK (April 2016). “Gout”. Lancet (Review). 388 (10055): 2039–2052. doi:1016/S0140-6736(16)00346-9. PMID 27112094. S2CID 208790780.
  4. Neogi, T (July 2016). “Gout”. Annals of Internal Medicine (Review). 165 (1): ITC1-16. doi:7326/AITC201607050. PMID 27380294.
  5. https://www.arthritis-health.com/types/gout/what-are-purines
  6. Kaneko, Kiyoko; Aoyagi, Yasuo; Fukuuchi, Tomoko; Inazawa, Katsunori; Yamaoka, Noriko (2014). “Total Purine and Purine Base Content of Common Foodstuffs for Facilitating Nutritional Therapy for Gout and Hyperuricemia”. Biological and Pharmaceutical Bulletin. 37 (5): 709–721. doi:1248/bpb.b13-00967. PMID 24553148.
  7. Choi HK, Atkinson K, Karlson EW, Willett W, Curhan G (March 2004). “Purine-rich foods, dairy and protein intake, and the risk of gout in men”.  Engl. J. Med. 350(11): 1093–1103. doi:10.1056/NEJMoa035700. PMID 15014182.
  8. Richette P, Bardin T (January 2010). “Gout”. Lancet. 375 (9711): 318–328. doi:1016/S0140-6736(09)60883-7. PMID 19692116. S2CID 208793280.
  9. Merriman, TR; Dalbeth, N (2011). “The genetic basis of hyperuricaemia and gout”. Joint Bone Spine. 78(1): 35–40. doi: 1016/j.jbspin.2010.02.027. PMID 20472486.
  10. Firestein, MD, Gary S.; Budd, MD, Ralph C.; Harris Jr., MD, Edward D.; McInnes PhD, FRCP, Iain B.; Ruddy, MD, Shaun; Sergent, MD, John S., eds. (2008). “Chapter 87: Gout and Hyperuricemia”. Kelley’s Textbook of Rheumatology (8th ed.). Elsevier. ISBN 978-1416048428.
  11. Chen, Yingchao (2020). “Association between serum vitamin D and uric acid in the eastern Chinese population: a population-based cross-sectional study”. BMC Endocr Disord. 20 (79): 79. doi:1186/s12902-020-00560-1. PMC 7268462. PMID 32493273. Retrieved 21 June 2021.
  12. Weaver, AL (July 2008). “Epidemiology of gout”. Cleveland Clinic Journal of Medicine. 75 Suppl 5: S9–S12. doi: 3949/ccjm.75.Suppl_5.S9. PMID 18819329. S2CID 40262260.
  13. Singh, JA; Reddy, SG; Kundukulam, J (March 2011). “Risk factors for gout and prevention: a systematic review of the literature”. Current Opinion in Rheumatology. 23 (2): 192–202. doi:1097/BOR.0b013e3283438e13. PMC 4104583. PMID 21285714.
  14. Schlesinger N (March 2010). “Diagnosing and treating gout: a review to aid primary care physicians”. Postgrad Med. 122 (2): 157–161. doi:3810/pgm.2010.03.2133. PMID 20203467. S2CID 35321485.
  15. Rothschild, Bruce M. “Gout and Pseudogout Workup”. Medscape. Updated: Jun 30, 2020
  16. Schlesinger N (March 2010). “Diagnosing and treating gout: a review to aid primary care physicians”. Postgrad Med. 122 (2): 157–161. doi:3810/pgm.2010.03.2133. PMID 20203467. S2CID 35321485.
  17. Sriranganathan MK, Vinik O, Pardo Pardo J, Bombardier C, Edwards CJ (11 August 2021). “Interventions for tophi in gout”. The Cochrane Database of Systematic Reviews.2021 (8): CD010069. doi: 1002/14651858.CD010069.pub3. PMC 8406833. PMID 34379791.
  18. https://upload.wikimedia.org/wikipedia/commons/5/52/Case_30-top.jpg
  19. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950134/
  20. https://ukrocharity.org/2014/08/top-news-on-uric-acid-and-gout/#:~:text=Gout%20can%20be%20triggered%20by,%25%20of%20cases%20%5BColton%5D.
  21. https://www.healthline.com/health/gout/can-different-parts-of-the-celery-plant-naturally-treat-gout#:~:text=The%20researchers%20found%20that%20luteolin,acid%2Dinduced%20inflammation%20in%20gout.
  22. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073821/
  23. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872714/
  24. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750830/#:~:text=Practical%20Applications&text=This%20study%20found%20that%20acupuncture,joints%20afflicted%20with%20psoriatic%20arthritis.

Depression & Aging, What Can Be Done, Invite Health Podcast, Episode 634

Depression & Aging, What Can Be Done, Invite Health Podcast, Episode 634

Subscribe Today! Please see below for a complete transcript of this episode. DEPRESSION & AGING, WHAT CAN BE DONE, INVITEⓇ HEALTH PODCAST, EPISODE 634 Hosted by Amanda Williams, MD, MPH *Intro Music* InViteⓇ Health Podcast Intro: [00:00:04] Welcome to the InViteⓇ Health Podcast where our degreed 

Dangers of Over-the-Counter Drugs & the Nutrients That May Get Depleted. Invite Health Podcast, Episode 633

Dangers of Over-the-Counter Drugs & the Nutrients That May Get Depleted. Invite Health Podcast, Episode 633

Subscribe Today! Please see below for a complete transcript of this episode. DANGERS OF OVER-THE-COUNTER DRUGS & THE NUTRIENTS THAT MAY GET DEPLETED, INVITEⓇ HEALTH PODCAST, EPISODE 633 Hosted by Amanda Williams, MD, MPH *Intro Music* InViteⓇ Health Podcast Intro: [00:00:04] Welcome to the InViteⓇ 

Psoriatic Arthritis

Psoriatic Arthritis

Written by Dr.Claire Arcidiacono, ND

For further questions or concerns email me at carcidiacono@invitehealth.com

In our last blog we completed our lupus discussion. This week we will be discussing another autoimmune disease called psoriatic arthritis. Psoriatic arthritis is a type of arthritis that occurs in individuals affected by psoriasis. In fact, psoriatic arthritis occurs in up to 30% of people with psoriasis. While in most people the skin changes of psoriasis precede the arthritis in up to 15% of individuals the psoriatic arthritis occurs before the rash. † (1)

Since psoriatic arthritis is an inflammatory disorder, its symptoms, include joints that are red, warm to the touch and joints that are swollen, stiff and there is often pain. In 70% of cases there is what is referred to as “asymmetrical oligoarthritis” which just means that the inflammation affects 2-4 joints during the first 6 months of the disease. Interestingly in 15% of cases the arthritis is symmetrical throughout the joints. In addition to causing joint pain a classic symptom of psoriatic arthritis is a swelling of the entire finger and or toes. This phenomenon is known as dactylitis. (2) Over time psoriatic arthritis may lead to arthritis mutilans which is a deformity of the joints that looks like a pencil in a cup on an X-ray.†  See Picture (3)

In addition to affecting the fingers and toes there can also be pain in the sacrum caused by sacroiliacs or spondylitis. Pain can also occur in the ankles. † (2)

Psoriatic arthritis is arthritis that occurs in an individual who has the condition psoriasis and thus symptoms of psoriasis are seen in addition to the joint symptoms. Psoriasis is an autoimmune condition that results in scaly skin, lesions that are normally present over the scalp, natal cleft, elbow and umbilicus. (4) Please see the added picture. † (5)

Psoriasis can also affect both the nails and even the nail beds. It can cause visible changes in these structures such as pitting, ridging of the nails, onycholysis and hyperkeratosis. It can also cause the nails to separate from the nail bed. (6) As a consequence of psoriatic arthritis being an autoimmune condition just like we saw in RA and lupus we can see some systemic symptoms. An example of one such symptom is fatigue. The fatigue is not corrected by sleep and may persist for days or weeks. (7) As with any autoimmune disorder there may be periods of remission and periods of “flare up” where the symptoms become less/more severe in intensity. †

One risk factor for developing psoriatic arthritis is having a peptide known as human leukocyte antigen (HLA) B27. (8)  Both psoriasis and psoriatic arthritis are usually considered to be genetic disorders that have been triggered by something in the environment. (9)  Flare ups can be triggered by stress as well as certain medications. Just like with other autoimmune conditions “bad guys” such as bacteria or yeast can increase the risk of both developing the condition or increase the risk of a flare up.  For example, studies have found an association between staphylococcus aureus, Malassezia and even Candida. † (10).

Nutritionally a vitamin D deficiency has been found to be associated with severe psoriasis and psoriatic arthritis. (11)  Additionally, being overweight or obese is an important risk factor for psoriasis and psoriatic arthritis. (12) As I spoke about in my blogs regarding lupus the standard American diet also called a western diet is also a risk factor for autoimmune disorders such as psoriatic arthritis. (13) Lastly once again as we spoke about during our lupus discussion is the interesting topic of leaky gut. As I stated previously leaky gut is associated with autoimmune disorders such as psoriasis and psoriatic arthritis. (14).  While there may be less common risk factors that can cause a flare up of psoriatic arthritis in this blog, I have just reviewed the most common. †

Several conditions can mimic psoriatic arthritis and must be ruled out before a diagnosis can be made. They include but are not exclusive to the following: Rheumatoid arthritis, osteoarthritis, gout, lupus and irritable bowel disease associated arthritis. † (15)

When working with psoriatic arthritis just like with any other autoimmune disorder we want to work on the underlying autoimmune aspect. By now in our series some of these suggestions will sound familiar to you. That is because as you can see, I only make suggestions that work either by showing studies, and by both looking at the research and my own clinical experience. †

WAYS TO MANAGE PSORIATIC ARTHRITIS:

  1. Diet: Working on getting to a healthy weight can help eliminate this risk factor and even help reduce symptoms of the disease after it occurs. (16) A Mediterranean diet has been found to help with autoimmune disorders. (17) In one study the Mediterranean diet helped reduce psoriasis symptoms by up to 29%! † (18)
  2. Vitamin D3 has been found in studies to be very important in the treatment of both psoriasis and psoriatic arthritis. (19) Please see Invite’s D3 1000, D3 3000, Liquid D and even our Immunity Hx! †
  3. Zinc has been found in studies to help with flare ups by reducing pain, inflammation and stiffness. Zinc has also been found to increase mobility. (20). Please see Invite’s Zinc lozenges, Zinc 30mg and our Immunity Hx. †
  4. Turmeric has been found to help with the swelling and pain of psoriatic arthritis. (21). Please see Invite’s Biocurcumin, and Curcumin blend.†
  5. Green lipped muscle has been found in studies to help modulate the immune system which helps with any autoimmune disorder. (22) In practicality I can say that it is very effective at reducing pain and inflammation. Please see Invite’s Inflammune. †
  6. Ginger has been found to help with both the inflammation and pain associated with autoimmune disorders such as psoriasis and psoriatic arthritis. (23) Please see Invite’s Turmeric with Ginger†
  7. Reduce stress – As we all know stress can make any chronic condition worse. By working to reduce this stress it can help reduce the risk of a flare up of the autoimmune disease.
    1. Magnesium has been found to reduce stress. (24) Please see Invite’s line of magnesium products.†
    2. L-theanine has also been found in studies to reduce stress. (25) See Invite’s L-theanine. †
    3. Fish oil is amazing for any autoimmune disorder since it helps reduce inflammation (26) and can even be helpful for stress. (27) Please see Invite’s Fish oil or Krill oil†
  8. Treat leaky gut – As we know leaky gut is a huge risk factor for any autoimmune. Supplements such as probiotics (28) can be very helpful in addressing this. For more information see my digestive health series! †

Catch Dr.Claire’s Digestive health series here–>DIGESTIVE HEALTH PART 10: ANAL FISSURES, FISTULAS & LEAKY GUT

While other supplements can be helpful, I have covered the ones I consider most important. To determine which supplements and dietary changes are best for you it is important to talk to an Invite nutritionist. Next week we will be discussing Gout. †

 

REFERENCES

  1. Ritchlin, CT; Colbert, RA; Gladman, DD (March 2017). “Psoriatic Arthritis”. New England Journal of Medicine (Review). 376 (10): 957–70. doi:1056/NEJMra1505557. PMID 28273019. S2CID 43867408.
  2. Amherd-Hoekstra A, Näher H, Lorenz HM, Enk AH (May 2010). “Psoriatic arthritis: a review”. Journal of the German Society of Dermatology. 8 (5): 332–9. doi:1111/j.1610-0387.2009.07334.x. PMID 20015187. S2CID 25484225.
  3. https://en.wikipedia.org/wiki/Arthritis_mutilans
  4. Menter A, Gottlieb A, Feldman SR, Van Voorhees AS, Leonardi CL, Gordon KB, et al. (May 2008). “Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics”. Journal of the American Academy of Dermatology. 58 (5): 826–50. doi:1016/j.jaad.2008.02.039. PMID 18423260.
  5. https://en.wikipedia.org/wiki/Psoriasis#cite_note-Menter2008-3
  6. Ritchlin, CT; Colbert, RA; Gladman, DD (March 2017). “Psoriatic Arthritis”. New England Journal of Medicine (Review). 376 (10): 957–70. doi:1056/NEJMra1505557. PMID 28273019. S2CID 43867408.
  7. Davidson, Stanley, Davidson’s principles and practice of medicine, Churchill Livingstone/Elsevier, p. 1096, 2010. ISBN 9780702030857. Accessed 2016-11-12.
  8. https://en.wikipedia.org/wiki/HLA-B27
  9. Menter A, Gottlieb A, Feldman SR, Van Voorhees AS, Leonardi CL, Gordon KB, et al. (May 2008). “Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics”. Journal of the American Academy of Dermatology. 58 (5): 826–50. doi: 1016/j.jaad.2008.02.039. PMID 18423260.
  10. Fry L, Baker BS (2007). “Triggering psoriasis: the role of infections and medications”. Clinics in Dermatology. 25 (6): 606–15. doi:1016/j.clindermatol.2007.08.015. PMID 18021899.
  11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486909/
  12. Prieto-Pérez R, Cabaleiro T, Daudén E, Ochoa D, Roman M, Abad-Santos F (August 2013). “Genetics of psoriasis and pharmacogenetics of biological drugs”. Autoimmune Diseases. 2013 (613086): 613086. doi:1155/2013/613086. PMC 3771250. PMID 24069534.
  13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034518/
  14. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767453/
  15. Davidson, Stanley, Davidson’s principles and practice of medicine, Churchill Livingstone/Elsevier, p. 1096, 2010. ISBN 9780702030857. Accessed 2016-11-12.
  16. Snekvik I, Smith CH, Nilsen TIL, et al. Obesity, Waist Circumference, Weight Change, and Risk of Incident Psoriasis: Prospective Data from the HUNT Study. J Invest Dermatol. 2017;137(12):2484-2490. doi:10.1016/j.jid.2017.07.822
  17. Phan, C.; Touvier, M.; Kesse-Guyot, E. et al. Association Between Mediterranean Anti-inflammatory Dietary Profile and Severity of Psoriasis: Results From the NutriNet-Santé Cohort.JAMA Dermatol. 2018;154(9):1017-24. doi:10.1001/jamadermatol.2018.2127
  18. Phan C, Touvier M, Kesse-guyot E, et al. Association Between Mediterranean Anti-inflammatory Dietary Profile and Severity of Psoriasis: Results From the NutriNet-Santé Cohort. JAMA Dermatol. 2018;154(9):1017-1024. doi:10.1001/jamadermatol.2018.2127
  19. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486909/
  20. https://pubmed.ncbi.nlm.nih.gov/7002197/
  21. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750830/#:~:text=Practical%20Applications&text=This%20study%20found%20that%20acupuncture,joints%20afflicted%20with%20psoriatic%20arthritis.
  22. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1388237/
  23. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9654013/
  24. https://www.ncbi.nlm.nih.gov/books/NBK507250/
  25. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836118/
  26. https://pubmed.ncbi.nlm.nih.gov/12480795/
  27. https://www.health.harvard.edu/mind-and-mood/omega-3s-for-anxiety#:~:text=Researchers%20found%20that%20people%20who,biological%20effects%20in%20the%20body.
  28. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864899/