UC-II® For Joint Support By Claudia Guy, N.D.

UC-II® For Joint Support By Claudia Guy, N.D.


claudia-guy, Joint
Claudia Guy, N.D.

Suddenly, one morning you wake up with a stiff, swollen, and painful joint. You most likely have arthritis. In the United States, more than 50% of individuals over 60 years of age have osteoarthritis, the most common form of arthritis followed by Rheumatoid Arthritis (1). Arthritis can be defined as inflammation in the joint, and is usually coupled with degeneration of the cartilage tissue. Arthritis pain generally worsens with weight-bearing activities such as exercising, stairs, walking uphill or even walking on a flat surface. These activities are all a part of daily living; which may lead to a decrease in quality of life.1 Undenatured type II collagen is a functional, natural product that may support joint degeneration due to normal wear and tear. More Americans are switching to natural products to slow progression of cartilage degeneration and promote healing.

The framework of human joint cartilage is primarily Type II collagen. Undenatured Type II collagen (UC-II) is derived from the sternum of chickens, and sourced and manufactured in the United States, where it is now available in a once a day capsule. Type II collagen for joint support was discovered decades ago. However, the use of chicken collagen was discovered in the early 2000s by researcher Dr. Moore, who was searching for a naturally safe treatment for his daughter in her 20s, suffering from incredible joint pain. His investigation and research led to the development of the correct preparation of type II collagen from chickens that proved most effective for his daughter’s joints. It is important that the sternum cartilage is undenatured, as cooking the cartilage destroys the therapeutic effects.1 UC-II is prepared using a low-heat, non-enzymatic process. The scientific preparation of glycosylation preserves the biological activity and therapeutic benefits of UC-II and is designated as GMP-certified and GRAS (Generally Regarded as Safe).1,2

Mechanism of UC-II

Chronic, strenuous mechanical stress on chondrocytes causes breakdown of cartilage, inflammation and the release of type II collagen into the blood stream. Because type II collagen is not supposed to be in the blood stream, it is recognized as foreign and is attacked by killer T-cells. These immune cells also attack type II collagen in the joints, which can lead to further inflammation. UC-II has been shown to slow the progression of arthritis via oral tolerance, a mechanism that works with the gut-associated lymphoid tissue (GALT or immune tissue) of the small intestine. When UC-II is orally administered, it interacts with the GALT to release T-regulatory cells that dramatically slows inflammation and deactivates killer T-cells.2,3

Clinical Trials

In one study, 40mg of UC-II was compared with 1500mg of Glucosamine Chondroitin. UC-II was found to be more effective than Glucosamine Chondroitin against stiffness and pain in the knee in climbing stairs, up from sitting, walking on a flat surface and even night pain. At the end of the 90-day study, UC-II reduced stiffness and pain 40%, whereas Glucosamine Chondroitin was 15%.1 Another study looked at joint pain from strenuous exercise on healthy joints. This was the first study of its kind. These experts felt that joint pain from strenuous exercise may indicate possible future joint problems. Their hopes were that UC-II might prevent damage to joints and preserve joint health. Subjects taking UC-II were able to exercise longer before experiencing any joint discomfort, and extended the offset of joint discomfort after exercising. Studies show fewer inflammatory makers with the use of UC-II.2 7 In these human clinical trials, UC-II showed statistically significance compared to placebo and glucosamine-chondroitin at only 40mg daily. In dogs, UC-II also shows significant decline in pain, stiffness over time, with no adverse effects.4,7

Current pharmacologic strategies for joint pain and degeneration mainly address anti-inflammatory and immune suppression mechanisms, both of which have limited success. Many studies support UC-II supplementation for joints to improve overall quality of life and activities of daily living.1 It supports arthritic, healthy joints, and joints that endure strenuous activities. Joint support is now in a convenient dose of one capsule a day. Take 40mg on an empty stomach prior to bedtime.1 UC-II has undergone rigorous third-party research and testing, and is proven effective, safe, and well-tolerated with no adverse effects.4,5,6,7 Now you can plan for long walks, adventurous hiking trails, or start training for the marathon.


  1. Crowley DC1, Lau FC, Sharma P, Evans M, Guthrie N, Bagchi M, Bagchi D, Dey DK, Raychaudhuri SP. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int J Med Sci. 2009 Oct 9;6(6):312-21.
  2. Lugo JP, Saiyed ZM, Lau FC, Molina JP, Pakdaman MN, Shamie AN, Udani JK. Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers. J Int Soc Sports Nutr. 2013 Oct 24;10(1):48. doi: 10.1186/1550-2783-10-48.
  3. Bagchi D, Misner B, Bagchi M, Kothari SC, Downs BW, Fafard RD, Preuss HG. Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration. Int J Clin Pharmacol Res. 2002;22(3-4):101-10.
  4. Deparle LA, Gupta RC, Canerdy TD, Goad JT, D’Altilio M, Bagchi M, Bagchi D. Efficacy and safety of glycosylated undenatured type-II collagen (UC-II) in therapy of arthritic dogs. J Vet Pharmacol Ther. 2005 Aug;28(4):385-90.
  5. Marone PA, Lau FC, Gupta RC, Bagchi M, Bagchi D. Safety and toxicological evaluation of undenatured type II collagen. Toxicol Mech Methods. 2010 May;20(4):175-89. doi: 10.3109/15376511003646440.
  6. Gupta RC, Canerdy TD, Skaggs P, Stocker A, Zyrkowski G, Burke R, Wegford K, Goad JT, Rohde K, Barnett D, DeWees W, Bagchi M, Bagchi D. Therapeutic efficacy of undenatured type-II collagen (UC-II) in comparison to glucosamine and chondroitin in arthritic horses. J Vet Pharmacol Ther. 2009 Dec;32(6):577-84.
  7. Gupta RC, Canerdy TD, Lindley J, Konemann M, Minniear J, Carroll BA, Hendrick C, Goad JT, Rohde K, Doss R, Bagchi M, Bagchi D. Comparative therapeutic efficacy and safety of type-II collagen (UC-II), glucosamine and chondroitin in arthritic dogs: pain evaluation by ground force plate. J Anim Physiol Anim Nutr (Berl). 2012 Oct;96(5):770-7.


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