Getting to Know Omega-3s – InVite Health Podcast, Episode 526
Your body needs omega-3s to function properly, but most Americans are lacking these important fatty acids. Here’s why that’s a problem for immunity, brain health and more.
Tag: immune system
Getting to Know Zinc – InVite Health Podcast, Episode 516
Zinc is the second most abundant mineral in your body, but many people don’t have enough of it. This nutrient is essential for immune health, brain function, heart health and more.
New Findings on Nutrition and Cancer – InVite Health Podcast, Episode 501
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Please see below for a complete transcript of this episode.
New Findings on Nutrition and Cancer – InViteⓇ Health Podcast, Episode 501
Hosted by Jerry Hickey, Ph.
*Intro music*
InVite Health Podcast Intro: Welcome to the InViteⓇ Health Podcast, where our degreed healthcare professionals are excited to offer you the most important health and wellness information you need to make informed choices about your health. You can learn more about the products discussed in each of these episodes and all that InViteⓇ Health has to offer at www.invitehealth.com/podcast. First time customers can use promo code PODCAST at checkout for an additional 15% off your first purchase. Let’s get started!
*Intro music*
Jerry Hickey, Ph.: [00:00:41] Recently, there’s been some very interesting findings in the field of cancer and nutrition, and I’d like to review that quickly for you today. So welcome to my episode, New Findings on Nutrition and Cancer. My name is Jerry Hickey. I’m a nutritional pharmacist. I’m also the Senior Scientific Officer over here at InViteⓇ Health. By the way, you could find all of our episodes on any place you’re listening to your podcasts, but also at invitehealth.com/podcast. Please subscribe and leave us a review. You can also find us on Facebook, Twitter and Instagram at @invitehealth. All of the information on today’s episode will be linked up to episode description, so let me review this. It’s very, very interesting stuff.† [00:01:26]
[00:01:29] The first report is on the mineral magnesium and magnesium specifically in its relationship with the immune system and with cancer. That’s from scientists at the University of Cambridge in the UK and the University of Basel in Switzerland. And magnesium… there would be different ways that magnesium would influence the immune system in a positive fashion. First of all, there’s a lot of data that cancer patients who have sufficient Vitamin D levels, they survive cancer much better. And you need magnesium to activate Vitamin D, so that’s very interesting and very important. In fact, there’s receptor sites on many immune cells for Vitamin D and these immune cells can activate Vitamin D. And then Vitamin D affects a whole bunch of genes that help govern the immune system. So Vitamin D is important for fighting infections, but it’s also important for fighting cancer. Plus, Vitamin D reduces inflammation, and cancer uses inflammation as a springboard to energy so it can grow and spread. So once again, there’s an important interaction between magnesium, which is needed to activate Vitamin D. Secondly, you need magnesium, the mineral magnesium, to release melatonin at night. If you don’t release melatonin at night, or if you release insufficient levels of melatonin, your immune system just doesn’t work well. That’s just not working at the appropriate time. And last of all, in my opinion, magnesium is also needed to stabilize energy. When you eat food and you breathe in oxygen, a lot of that goes towards the Krebs citric acid cycle, where you’re turning sugar into energy. And once you have that energy, it’s a molecule called ATP. It’s a nucleotide called ATP, that’s responsible for almost all your energy. You need to stabilize it by attaching magnesium to it. Otherwise, it’s going to just flare up and be used up before you can even get any benefit out of it. So 90% of your energy is attached to the mineral magnesium. So there’s different ways that magnesium can influence the immune system because if you don’t have enough energy, the immune system is a high energy group of cells, if they don’t have enough energy, they’re not going to do a great job of fighting for you. So the scientists at Cambridge University and University of Basel, they discovered that your killer T cells can only kill cancer cells or fight infections if they’re in the presence of sufficient magnesium. So if there’s not enough magnesium near these T cells, not enough of them are going to be activated. [00:04:24]
[00:04:26] Now, looking at other clinical trials using cancer immunotherapies, they found that lower levels of magnesium in the blood serum led to more rapid growth and spread of the cancer and shortened survival of the patient. Magnesium’s involved in over 600 chemical reactions in the human body. It’s very important for your metabolism, and many of these reactions involve your immune system and immune system functions and immunity.† [00:04:58]
[00:04:59] So what’s a natural killer cell? You have basically two parts of the immune system the innate immune system, which is not educated. It’s just kind of like a blunt force, blunt force trauma against germs and cancer, but it has to be guided. And then there is the acquired immune system, which is educated. It’s like an intelligent part of the immune system and that consists of B cells, which have antibodies, plus antibodies and other places. Antibodies fit an infection specifically. So when you have antibodies against COVID-19, they fight COVID-19, they don’t fight the flu. And when you have antibodies against the flu, they fight the flu. They don’t fight COVID-19. So antibodies are part of the acquired immune system, which is like the intelligent part of the immune system and then natural killer cells, which are really cool cells, they kind of have a little bit of a memory, a short-term memory, and, see, they kind of fill a gap, natural killer cells. The first part of the immune system to attack an infection, and this part doesn’t work very well in adults, is the innate immune system with neutrophils. They’re also called polymorphonuclear leukocytes. We kind of don’t have great functioning neutrophils when you’re older, but they kind of handle the infection for, let’s make believe three days. You know, it’s hard to say exactly, but three days, then they start to peter out. They get fatigued. The natural killer cells bridge the gap between when they’re starting to not function as well and when you have enough time to make antibodies, antibodies specific for the infection, which can take a week, 10 days.† [00:06:31]
IMMUNE SYSTEM, PART 1: THE BASICS – INVITE HEALTH PODCAST, EPISODE 491. Listen Now>>
[00:06:33] So the the acquired immune system’s really important and then there’s the T cells. The T cells shred infections, the T cells shred cancer tumors, cancerous tumors and cancerous cells if they know where it is. So many of the new or very advanced therapies for cancer take a sample of your cancer. See, every cancer has different mutations that are a signature for that specific cancer. So if you had 100 men in a room with prostate cancer, every one of those cancers would have different mutations. So they train… They take out your T cells and they train them to look at the mutations in your particular cancer. And then they load you up with those T cells and those T cells can recognize the cancer, hunt it down and kill it. But it turns out these killer T cells require, they require the presence of magnesium for them to really work. So if you’re lacking magnesium, even though you have these killer T cells, they don’t have the energy to do their job. So this is really important data.† [00:07:44]
[00:07:45] Now here’s a second study. It’s in the journal Cancer. It’s the University of Buffalo, the University of Buffalo School of Public Health and the University of Buffalo School of Pharmaceutical Sciences. And they found that 68% of cancer survivors report that they use nutritional supplements. Now, that’s really important data because they found that the cancer survivors that use nutritional supplements, they survive better, they survive the cancer better, they live longer and they live cancer-free longer, apparently. But they also had lower rates for hospitalizations, and they also had a better quality of life. So what’s a better quality of life? You know, having the energy to go outside and be active, having the energy to be social, having good brain function, that sort of thing. Quality of life, what makes your life worth living. That was a 10-year period that they watched these cancer survivors. And they found that the supplements basically cost about a dollar a day, but here’s what they found. Because the supplements kept people out of the hospital, it was a lot less expensive to use the supplements than not use the supplements because one trip to the hospital cost more than the supplements. So the people on the supplements had a lower rate of hospitalization and they survived better and they had a better life, better quality of life.† [00:09:09]
[00:09:10] So there are nutrients that we know work very well in cancer patients to begin with, but also in cancer survivors. One of them is Vitamin D. The Vitamin D helps reduce inflammation. Cancer feeds off inflammation to get the energy to grow and spread and the wherewithal to grow and spread. But Vitamin D is also needed for activating and guiding specific immune cells, so people who have sufficient Vitamin D over the course of their cancer treatment tend to do better, but they also survive better. They’ve seen this with a number of different cancers, including breast cancer, certain leukemias, prostate cancer. I believe colon cancer, but I’d have to double check that one. And you want your Vitamin D level, ideally between like 45 and 65. Like 55 is a beautiful, beautiful level of Vitamin D in your blood.† [00:10:01]
[00:10:02] Another supplement that there’s a good amount of research that is helping cancer patients is a good probiotic. Look for strains such as Lactobacillus plantarum, Lactobacillus ramnosis, bifidobacterium animalis subspecies lactis. These are really important for immune system function. So there’s a number of studies now that are showing that cancer treatment works better in the presence of these healthy bacteria and survival seems to be better also.† [00:10:29]
[00:10:31] Other supplements that may be helpful: magnesium that needs more work, but it certainly seems to be something. If your, if your killer cells, you, your killer T cells, require magnesium to function, that makes it very important for treating cancer. And then some people melatonin, because melatonin is needed for a properly-functioning immune system. So if you’re not sleeping at night, you can have a doctor check the level of melatonin metabolites in your urine the next morning. And if it’s low, you probably need melatonin, that should help the body fight cancer. There’s a lot of evidence building, there’s a good archive of it actually, that people who lack melatonin have a higher risk of a whole bunch of cancers.† [00:11:13]
[00:11:15] Beyond that, certain foods like green tea. But here’s a caveat. Don’t put milk in green tea. There’s some evidence it doesn’t work as well with milk. Put some lemon in there. Put some kind of citrus in there. The citrus ingredients shield the delicate polyphenols in green tea from your digestive enzymes in your stomach acids and you absorb more of them and they’re intact, so you’ll get a better return for your health if you do that with your green tea. But green tea in many ways helps fight cancer, so people who survive cancer come see me, I say, “Well, listen, you have to do green tea.” I also tell them to eat a lot of berries, dark berries and apples, and maybe even some high quality cocoa, even some red grapes. Or take some resveratrol because the anthocyanins and the flavan-3-ols are very healthy for their brain and their heart and their immune system, survival in general. I told them, have cabbage vegetables about five times a week. Cabbage vegetables could be bok choy, broccoli rabe, kale, collard greens. I don’t normally tell them Brussels sprouts because that can have a lot of heavy metals in it. So I don’t normally tell them Brussels sprouts, but broccoli itself, cabbage because there’s a whole bunch of things in cabbage vegetables that the good bacteria in your intestines convert into cancer-fighting nutrients like there’s isothiocyanates that convert to sulforaphane. There’s glucuronic acid. There’s indole-3-carbinol, which converts to diindolylmethane. All these are cancer fighters. However, there’s a caveat with cabbage vegetables, too. If you eat them raw, they can block your thyroid function. They can decrease your thyroid function, which is not good for the immune system. But if you cook them, you get rid of the things that affect the thyroid, they’re called goitrogens. But even cooked, I wouldn’t have them more than five days a week. So cabbage vegetables five days a week help in the fight against cancer and viruses, not a bad thing. A multivitamin is always helpful.† [00:13:22]
[00:13:23] So thanks for listening to my episode today. You can find all of our episodes wherever you listen to podcasts or just go to invitehealth.com/podcast. You can also find us on Twitter, Instagram and Facebook @invitehealth. Please subscribe and leave us a review. I want to thank you for listening, and this is Jerry Hickey signing off. By the way, if you’re going to use supplements during your treatment for cancer, you really have to pass that by your oncologist, the doctor managing your cancer for approval because there’s different forms of cancer treatment, and we would never want to interfere with them, even though that would be not very likely. It’s still important to check this with the doctor.† [00:13:23]
*Exit music*
Chronic Inflammation, Part 2 – InVite Health Podcast, Episode 499
Chronic inflammation can wreak havoc on the body, so what can you do to help? Turn to powerful nutrients such as Vitamin D, resveratrol and more to help with inflammaging.
Immune System, Part 4: Diet and Supplements – InVite Health Podcast, Episode 494
In this episode of the InVite Health Podcast, Amanda Williams, MPH concludes her series on the workings of the immune system. Learn about the important role nutrients such as Vitamin A, Vitamin E and mushroom extract play in your immune defenses.
Immune System, Part 3: Autoimmune Disorders – InVite Health Podcast, Episode 493
immune system
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Please see below for a complete transcript of this episode.
Immune System, Part 3: Autoimmune Disorders – InViteⓇ Health Podcast, Episode 493
Hosted by Amanda Williams, MPH
*Intro music*
InVite Health Podcast Intro: Welcome to the InViteⓇ Health Podcast, where our degreed healthcare professionals are excited to offer you the most important health and wellness information you need to make informed choices about your health. You can learn more about the products discussed in each of these episodes and all that InViteⓇ Health has to offer at www.invitehealth.com/podcast. First time customers can use promo code PODCAST at checkout for an additional 15% off your first purchase. Let’s get started!
*Intro music*
Amanda Williams, MPH: [00:00:39] We’ve come to part three on our immune system podcast series, where I’m going to be discussing autoimmune conditions, what that actually means, and understanding the difference between passive and active immunity. So I’m Amanda Williams, MD, MPH, and we’ve covered a lot of ground. We’ve talked about the immune system, how its basic function is, talked about the impact of inflammation, talked about the end results of an aging immune system and immunosenescence. So today I want to talk about autoimmune and looking really at passive and active immunization. So when we think about the way that our immune system reacts when we’re exposed to a particular virus or bacteria, whatever pathogen it may be, we have a immune system response. So we have this acquired immunity, which is attained either through passive or through active immunization. So when we think about passive immunization, this is really talking about the transfer of immunity and this goes from one person to another. So when we think about maternal antibodies being passed off to the developing baby, so that would be an example of that passive immunity. So we can also get passive immunity through antibody-containing blood, such as an immune globulin. So you see certain disease conditions where immune globulins are utilized. So this is a form once again of passive immunity.† [00:02:31]
[00:02:33] Now, when we think about active immunity, this results when we have exposure to a particular disease organism that triggers the immune system to produce antibodies. So what are we now thinking about? We are thinking about antibody or adaptive or delayed immune response. So active immunity can be acquired through natural immunity or through vaccine-induced immunity. So natural immunity means we’re exposed to a particular pathogen and our body creates a means to fend this off if we are exposed to it again. Now, vaccine-induced immunity is acquired through either, you know, a killed vaccine or a weakened formed of that vaccine. There’s many different vaccines. Now we have the mRNA vaccines. So in either way, if the person comes in contact with that particular disease pathogen in the future, then the immune system recognizes this and will immediately produce the antibodies needed to fight it. So active immunity is very long-lasting in many cases, and in certain conditions, it’s actually lifelong. So when we think about someone who gets vaccinated for hepatitis B, for example, that has a long-lasting immunity. Now there’s other types of pathogens, when you think about tetanus, for example. Someone has to get re-vaccinated to that. So when it comes to understanding vaccination, this is quite complex. But at the end of the day, we know that the immune system works via active immunity and passive immunities. Passive immunity is what we get when we’re born or if we’re going under treatment for an immune globulin treatment therapy. Active immunity is going to be derived either via natural immunity or through vaccine-induced immunity.† [00:04:38]
[00:04:40] So how can things go haywire? This is where we come in to autoimmune. So an autoimmune disease or disorder occurs when the body’s immune system attacks the body. And usually when people think about autoimmune conditions, they think of the most common ones. You think about rheumatoid arthritis, you think about lupus, Graves’ disease, Hashimoto’s, psoriasis. These are common. There’s hundreds of autoimmune conditions and some are very common. We know that in the United States alone, one out of every 15 people, one out of every 15, has an autoimmune condition. So when we think about things like ulcerative colitis, Crohn’s disease, myasthenia gravis, type one diabetes is an autoimmune condition. Understanding how this occurs is what’s important because we know that when our immune system is exposed to something, it’s going to eventually generate antibodies to this particular antigen. When the immune system cannot distinguish between what’s healthy and what is not, then it starts to destroy or attack the healthy organ or the healthy cell. And hence this is a big problem. So we see this in rheumatoid arthritis when the immune system is driving up this inflammatory response within the joint and it’s destroying that joint. So that destruction of a tissue, the abnormal growth of an organ, the change in function of an organ… We see this in Graves’ disease and Hashimoto’s thyroiditis. We know that autoimmune conditions can affect more than one system, more than one organ. We know that one autoimmune condition can drive another autoimmune condition in the body. And we’ve seen this. It’s becoming more common where you can have multiple autoimmune disorders.† [00:06:48]
[00:06:51] So how does this happen? How is it that the immune system just decides to go haywire and start attacking? Well, there’s many different schools of thought on this, but one of the most common theories out there is that it’s driven because of microorganisms. So when we think about different bacteria, viruses, drug-induced autoimmune can trigger a change in the immune system because remember, we’re dealing with this multi-functional system, remember, that’s reliant on micronutrients, macronutrients, fatty acids, the gut microbiome. So if something occurs that shifts, say you have a viral infection, and because of that viral infection, the immune system gets a little confused and it’s like, “I’m not sure what we’re supposed to be doing here. Let’s just try and destroy.” That’s a big problem.† [00:07:51]
[00:07:53] They just came out in the last month and are looking, Cedars-Sinai are finding evidence of overactive immune response, meaning the immune system goes haywire, as I describe it, when we’re talking about autoimmune in the setting of SARS-CoV-2. That’s the virus that causes COVID-19. We know that there’s all of these different autoantibodies, when people talk about natural immunity that the body generates. The problem that they’re finding is that many people who are asymptomatic or mild symptoms have these autoantibodies that are stressing the immune system to such a degree, and they are persistent much longer over time, so we’re not talking about natural protective immunity. What we are looking at is autoantibody, so that autoimmune, which is linking people to these problems with chronic inflammation, post-COVID infection that’s affecting joints, that’s affecting the nervous system. Many of these autoantibodies that they are detecting are being linked to autoimmune conditions. Remember, I said when the immune system goes haywire, one thing can spiral out of control to affect another thing. So if we can see that an infection with COVID can trigger and drive these variable responses, then we need to once again be focusing on that. How do we strengthen the immune system? How do we go about making sure that the immune system isn’t taking an exposure to an antigen and creating an autoantibody to that? So autoimmune disorders are very problematic. And to rid the system of an autoimmune condition is very hard.† [00:10:02]
[00:10:03] I mentioned a lot of these diseases, you see how far they’ve made it with many of them not far. They give people different drugs, immunosuppressant drugs to try to downregulate that immune system over-response. You have different medications that help to try to regulate thyroid function in the setting of autoimmune thyroid conditions. But at the end of the day, we have to be cognizant of the fact that our immune system goes through so much from the time that we’re born to the time that we leave this world, and when we factor in nutrient depletion, when we factor in immunosenescence, when we factor in stress and the impact that lowering levels of DHEA can play, chronic autoimmune diseases are becoming more readily acquired, we can say. Seeing more and more people who are being diagnosed with autoimmune conditions. And many of these things are tracing back to different infections. So we can’t fool ourselves and say, “OK, because I had an exposure to this, now I have natural immunity.” Because sometimes that natural immunity backfires and we actually generate autoantibodies, which are now destroying good, healthy tissues and organs and pathways.† [00:11:38]
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[00:11:42] So understanding how the immune system is working, understanding that passive immunity, understanding passive immunity is short term. It’s like the innate immune response, it’s short term. Passive immunity generally only lasts for a few weeks or few months. Active immunity, which correlates with our adaptive immune response, is longer lasting. So there’s a lot of moving parts, once again, when we think about our immune system and the causative reasons as to why our immune defenses can get so incredibly disrupted. When you see people who have an autoimmune disease. And they’re given these really costly, incredibly expensive and often come with a whole list of nasty side effects, these different medications that suppress their immune system, which now leaves them more vulnerable to another infection.† [00:12:53]
[00:12:56] So there’s a lot of different ways that we can help to regulate our immune system. There are many ways in which we can make small modifications to our diet, to our exercise, making sure we’re getting adequate exposure to those micro and macronutrients to enhance the body’s ability to fend off any type of a pathogen and to boost the immune function. There’s so much research out there now that shows how different nutrients, different herbal extracts can help to enhance or downregulate the way that the immune system is over-producing these different cytokines and prostaglandins. So the overactive response by the immune system can certainly get us into trouble, so we need to make sure that the immune system knows when to turn on and when to turn off. And the best way in achieving this is through healthy lifestyle. And you can do everything right. You can be eating right, exercising and still end up with an autoimmune condition. Yeah, there can be a genetic variant that’s the driving cause, can be an environmental exposure that’s unavoidable that can be weakening the immune system. But we have so much control over the action of our immune system. But you have to take the right steps. So on the next podcast, I’m going to talk about nutrients. Nutrients to support our immune system. And there are so many. We’ll look at the basic nutrients. We’ll look at some of the advanced ways in which different herbal extracts can help to enhance. We think about mushroom extract, for example, all of the different ways that we can take different supplements that can help to enhance our immune defenses.† [00:15:01]
[00:15:01] So I want to thank you so much for tuning in to the InViteⓇ Health Podcast. Remember, you can find all of our episodes for free wherever you listen to podcasts or by visiting invitehealth.com/podcast. Now, do make sure that you subscribe and you leave us a review. You can follow us on Facebook, Twitter and Instagram @invitehealth and we will see you next time for another episode of the InViteⓇ Health Podcast. [00:15:01]
