An Anti-Aging Supplement, Quercetin – InVite Health Podcast, Episode 567
Please see below for a complete transcript of this episode.
An Anti-Aging Supplement, Quercetin – InViteⓇ Health Podcast, Episode 567
Hosted by Jerry Hickey, Ph
InViteⓇ Health Podcast Intro: Welcome to the InViteⓇ Health Podcast, where our degreed healthcare professionals are excited to offer you the most important health and wellness information you need to make informed choices about your health. You can learn more about the products discussed in each of these episodes and all that InViteⓇ Health has to offer at www.invitehealth.com/podcast. First time customers can use promo code PODCAST at checkout for an additional 15% off your first purchase. Let’s get started!†
Jerry Hickey, Ph: [00:00:40] What I’m going to tell you in these first several sentences is absolutely true. Throughout our life, we create zombie cells in a process called cellular senescence. And when we’re young, our very youthful and active immune system can pluck them out and rid us of them. But as we get older and our immune system ages, we lose the ability to remove the cells and they build up all over our body, including in our brain. And they lead to, weakness. They’re destructive, they lead to disease. They accelerate the aging process. They make the aging process a very bad experience. So the cells are called senescent cells, and a very safe and natural ingredient can help restore your ability to remove them slowing down and improving your journey through the aging experience. † [00:01:32]
[00:01:33] Hi, my name is Jerry Hickey. I am a nutritional pharmacist, a licensed pharmacist. Welcome to my episode! Quercetin slows down and improves your aging experience and there are several other natural ingredients that also help you accomplish this. I’ll go into that. At the end of this episode, you can find all of our InViteⓇ episodes for free wherever you listen to podcasts, or just go to invitehealth.com/podcast and please subscribe and leave us a review. You can also find us on Twitter, Instagram and Facebook at InViteⓇ Health. † [00:02:08]
[00:02:11] So the technical name for these zombie cells are senescent cells. So senescent. Think of senile, old, doddering, slowing down. Now to create new, healthy young cells, our cells have to divide to replace the old cells with new cells. At some point in a cell’s life, this process can stop. So in young people, it’s usually due to disease and infection and accident. But once again, their immune system is very active and are able to pluck out these cells. If you can’t pluck them out, if your immune system isn’t working well enough to pluck them out, they become very toxic. And they contribute to a slowing down of the healing process. They contribute to many diseases, they contribute to weakness and loss of muscle and fatigue, a poor aging experience. They’ve even been found to contribute to bone loss with aging. † [00:03:14]
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[00:03:16] So, the cells in question, the senescent cells, they’re not functioning. They’re basically dead, but they’re still releasing chemicals, immune system chemicals that signal the immune system to cause destruction and inflammation. Cytokines and chemokines are called such as interleukin six, which is abbreviated IL-6. Now you probably heard about interleukin six during the COVID pandemic because the patients in the hospitals, when their lungs were getting destroyed, it was from a surge of this IL-6. So these cells released chemicals like IL-6 that are very bad for us, but they also release chemicals like CRP, C-reactive protein. CRP is usually released from the liver when you’re inflamed and we don’t exactly know what CRP does, but it is a proxy for inflammation and it’s very destructive when CRP is elevated. So how does the immune system remove these zombie cells? Well, natural killer cells can adhere to them and target them and kill them. And then macrophages, these huge immune cells, literally gobble them up and dissolve them in a process called phagocytosis. † [00:04:37]
[00:04:39] The problem is our natural killer cells, although we have an abundance of them with aging, they’re not working. So that’s interesting because another way to look at this is for nutrients that improve the function of natural killer cells like zinc and like vitamin D, and another one would be certain probiotics like Bifidobacterium animalis subspecies lactis. That’s another way of looking at this, that make your natural, natural killer cells work better. Now, these zombie cells, the senescent cells, they release these chemicals that destroy neighboring cells. And in time this leads to sarcopenia, which is a frank loss of muscle and strength, leading to fragility syndrome. Where you’re shrinking, you’re becoming inactive, you’re not communicative. Basically, you’re sitting in a chair all day staring at the fish tank. So it can damage your organs, for instance, in the brain. These cells are part and parcel of developing Parkinson’s disease, which happens near the back of the brain. It’s a movement disorder. It affects your muscles and eventually can affect your muscles and your diaphragm, you know, your breathing muscles or in a front more towards the front of the brain. Alzheimer’s disease, in your eyes. These cells can contribute to cataracts, clouding of the eyes and glaucoma are pressurized, which damages the retina and can damage your vision. Lung diseases, even a buildup of scar tissue in the lungs, fibrotic tissue, we call that. Arthritis of the joints, loss of bone, Diabetes, Type two diabetes. You know, we used to call it adult onset diabetes, except we’re seeing it in kids now. Heart disease and heart failure and even cancer. † [00:06:25]
[00:06:29] So, not only can these senescent cells because they trigger inflammation, they trigger free radicals, they trigger tissue destruction and mutations in your DNA, which gets copied. Not only do they contribute to the onset of cancer, but they contribute to the spread of cancer. So you don’t want these cells around. Cellular senescence is an underlying mechanism. It’s absolutely an underlying mechanism for unhealthy aging, for developing frailty and weakness, and for age related diseases, including cancers. † [00:07:06]
[00:07:08] Now removing senescent cells in animals. A lot of studies were done by the Mayo Clinic, by the way, over in Rochester, Minnesota. But they’re not the only ones doing these studies. Removing senescent cells in animal studies increases their lifespan. Now, I’m not talking about maximal lifespan. I’m not talking about sort of maximal lifespan for humans of some somewhere in like 122 years. It’s not like you take these things to make you live to 150 years. What it does, it helps you get to 120 years. So, you live more of your natural lifespan and it also helps you with your health span, which is how long you stay healthy, because the health span clearly is as important as lifespan. You don’t want to live to 95 but be sick for the last 30 years of your life. You’d rather shovel all that sickness into the last week of your life, right? So that’s kind of what we’re trying to do here. † [00:08:00]
[00:08:02] So, senescent cells, let me put this way. They damage us in at least four major ways. They crowd out our healthy cells. So this can damage the function of organs and weakened organs like the lungs and the liver and kidneys, and the brain, the organs don’t function as well. They interfere with progenitor cells and stem cells. So that helps prevent the formation of healthy tissue. So think if you’re trying to get your muscle back, it’s harder to get your muscle back. But that would also interfere with healing. That would also damage the heart and lead to heart failure. Now, another way senescent cells are powerful factories releasing these chemicals that foster free radical formation and inflammation. This leads to diseases accelerating the aging process, making aging a terrible experience for us. So the senescent cells, they’re damaging your surrounding tissue by creating these free radicals, which trigger inflammation, which leads to disease. † [00:09:13]
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[00:09:14] Now, the last thing is the senescent cells contribute to causing cancer and also spreading cancer. So senolytics are the answer to that. Senolytics are a class of small molecules that help restore the ability to remove these senescent zombie cells. Some drugs had this ability. But I have to tell you, as a licensed pharmacist who’s been around for many decades, I would urge caution with these drugs that have potential toxicities. Not to mention that they’re prescriptions. However, there are several safe, naturally sourced analytics. My favorite is Quercetin, I take it every morning. Quercetin is a flavonoid, there’s thousands of flavonoids they do very good things for us. These are plant substances that help protect our cells. They have anti-inflammatory activity, they have antioxidant activity. So they help slow the aging process in general. But Quercetin in particular has the added advantage of it helps get rid of these zombie cells. So that’s an additional plus for Quercetin. Now, Quercetin is very good for people with allergies. It’s great for it. There are a number of herbs and nutrients that are good for allergies that work very well, Quercetin is one of them. It’s great for our health. That’s great for circulation. In fact, people who take people at high blood pressure, who take 500 milligrams of Quercetin three times a day with their meals, it helps lower their blood pressure back towards normal to beauty. Quercetin, often that can cause low blood pressure. It’s not as strong as prescription drugs, but you could safely add it to the prescription drugs for added benefit to lower your blood pressure. It’s good for men’s prostate. It may help women with interstitial cystitis for the inflammation in the bladder or in the urinary tract. It’s good for the urinary tract in general. It’s good for the eyes, it’s very good for the lungs. So Quercetin has many good benefits. † [00:11:16]
[00:11:16] Now, normally you’re getting some Quercetin if you eat a healthy diet. So when you’re eating blueberries or apples or broccoli or you’re drinking green tea or onions and garlic or citrus fruit like an orange, you’re getting some Quercetin. But even a very good diet only has about 25, maybe 50 milligrams a day in it. So when I started reviewing the studies on Quercetin as a senolytic agent, I decided to step up my intake. I’ve known about senolytics now for about, I don’t know, ten, 15 years. But only recently, I felt that the research is really getting there. So I added I only added a week ago. I added 500 milligrams every day to my breakfast, and 2019 the Mayo Clinic, which has done a lot of the research on senolytics, found that the prescription drug, Dasatinib and Quercetin both remove senescent cells from the bodies of aging elderly people like me. So this is wonderful, and the effect started within the first three days. Now, the problem with Dasatinib is it’s a drug normally used to treat leukemia. So I really would stick with the Quercetin. † [00:12:37]
[00:12:39] Now another natural senolytic is Fisetin. Fisetin, is similar to Quercetin. Interestingly, both Quercetin and Fisetin are found together in certain healthy foods like apples, strawberries, onions, peaches, tomatoes, cucumbers. So it’s good practice to eat these foods. I mean, there’s a reason why you want to eat healthy foods. So my recommendation, if you’re older, you know, Quercetin, also seems to get a boost when you take it with vitamin C, they seem to work in a synergistic fashion. One potentiated the benefits of the other. So I like to either eat something with vitamin C or take something with vitamin C at the same time I’m taking my Quercetin. † [00:13:29]
Jerry Hickey, Ph: [00:13:32] So in any event, thanks for listening to today’s podcast episode. You can find all of our episodes for free wherever you listen to podcasts, or just go to invitehealth.com/podcast. You can also listen to us on Instagram, Twitter and Facebook at InViteⓇ Health. Once again, thanks for listening. Hope to see you next time in another episode of the InViteⓇ Health podcast. Jerry Hickey signing off. † [00:13:32]