Feeling Energized Again with the Anti-Fatigue Program
More than 20% of Americans deal with fatigue. The good news is that there are nutrients that can help!
Tag: energy
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What Is Brain Fog? – InVite Health Podcast, Episode 517
brain fog
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Please see below for a complete transcript of this episode.
What Is Brain Fog? – InViteⓇ Health Podcast, Episode 517
Hosted by Amanda Williams, MPH
*Intro music*
InViteⓇ Health Podcast Intro: Welcome to the InViteⓇ Health Podcast, where our degreed healthcare professionals are excited to offer you the most important health and wellness information you need to make informed choices about your health. You can learn more about the products discussed in each of these episodes and all that InViteⓇ Health has to offer at www.invitehealth.com/podcast. First time customers can use promo code PODCAST at checkout for an additional 15% off your first purchase. Let’s get started!
*Intro music*
Amanda Williams, MPH:
[00:00:40] When it comes to brain health, we all want to try and do everything that we can in terms of making sure our brains last a lifetime for us, right? But many folks experienced something known as brain fog, and I want to talk about brain fog in some detail today and some nutrients that can be beneficial when it comes to the issues that arise with brain fog. So I’m Amanda Williams, MD, MPH, and brain fog in general. When we just hear that term, like, “I just feel like cloudy in the head.” And oftentimes people feel like this after they’ve been sick or while you’re sick. So you get the flu and you just feel like, ugh, your head feels kind of stuffy and you feel like you just can’t focus. What we recognize brain fog to be is a general decrease in mental energy and focus. Now, who wants to have that? Who wants to feel mentally fatigued and feel like you can’t focus? Not too many folks out there. So we oftentimes just kind of put it into this reference of like a fog. And if you’ve ever had a drive in fog before, you know that that’s not a fun experience. So this clouding that can lead to forgetfulness or just kind of feel fuzzy and maybe a little confused, or maybe you’re trying to do a task and you’re having a difficult time concentrating with this. This can be incredibly annoying.† [00:02:03]
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[00:02:04] So when it comes to brain fog, we always want to try and figure out what is the root cause of this and how do we address it? Well, we know that there are many different conditions that can drive up this kind of mental taxing load in our brains. We think about inflammatory disorders. There can be sensitivities to certain foods that maybe create this. So when people eat maybe dairy, they feel kind of cloudy in the brain, and this is actually a lot more common than we recognize. We know that when people have brain fog on a regular basis, we must always look at histamine and the over release of histamine, which can drive this irritation and inflammation within the brain. And what happens is we’re actually creating this imbalance in our neurotransmitters. And so the little tiny neurons in the brain that are responsible for releasing these very important neurotransmitters, they’re not working very efficiently.† [00:03:07]
[00:03:08] So we want to think about ways that we can target this. How can we utilize different nutrients that can be beneficial when it comes to neuroinflammation or inflammation that’s occurring in the brain? So we know that there’s a lot of different things out there, including things like resveratrol, for example. They’ve done multiple studies with resveratrol and seeing how that actually works by a couple of different pathways for targeting the inflammation and helping to enhance the way that our brain is functionally working in a much, much more efficient way. Phosphatidylserine, one of those key phospholipids in the brain that helps to support the, the actual structure of your neurons or the brain cells. But also when we think about making acetylcholine, phosphatidylserine’s very important for this. We know that when our brains are stressed out, say, for example, you’re going to do a big interview or you have a big exam at school or whatever might be driving up your stress in your life, we know that when we utilize phosphatidylserine, this key membrane fat, that it does a couple of different things for us. Number one, it helps to make sure that those brain cells aren’t getting dinged around. That’s key. The other thing that we know it does is it helps with the regulation of our adrenal glands. And this is really important because we have to recognize that it’s not only a neurotransmitter slash inflammation process that drives up brain fog, but it’s certainly linked to hormonal imbalance. So you have a lot of people who have thyroid dysfunction who will experience brain fog, and this is one of the big complaints that folks who have like underactive thyroid will say, “I just feel foggy in the brain all of the time.” Or here’s probably the biggest example is women going through menopause or postmenopausal women will complain oftentimes about having brain fog, like “I just feel like I have cobwebs in my brain and I can’t think as quick as I used to, and I just don’t feel as focused,” and this can be really detrimental to our health because then you’re just irritated all the time because your brain is not feeling as youthful as it once used to.† [00:05:23]
[00:05:23] So we know that balancing our hormones is certainly important, and there’s a lot of different ways we can do this, even outside of doing actual hormone replacement therapy. We can utilize different nutrients that can help when it comes to the regulation of different hormonal pathways. So one more thinking along the adrenal pathway, we can think about things like rhodiola. This is a really nice way for us to get our brain back in check. They’ve done studies with rhodiola where they find that when they put people in a high stress environment and they give them rhodiola, their mental capability to be able to focus on their task without letting that exterior stressor basically kind of screw everything up, that rhodiola works really good in this setting. Now, the nice thing about rhodiola is that it also generates up energy, so you’re going to feel like you have more energy, and at the same time, you’re going to have this much more acute focus. So hence that brain fog is leaving.† [00:06:22]
[00:06:23] Now, if we’ve got problems with our blood glucose, we know that this can impact our brain. So if we have insulin resistance, then we want to make sure that we’re incorporating in things like chromium, alpha lipoic acid. Certainly things that we know can help our body when it comes to waking up those insulin receptors. And this is very important. Now, we have to always be cognizant of the foods that we’re eating. If we’re having bad foods, high sugar foods, this is going to just exacerbate that brain fogginess. So we want to have high fiber foods, foods that are packed with powerful antioxidants. So what am I talking about? Fruits and vegetables. We know that the fruits and vegetables really can do so much when it comes to our brain health. Look at blueberries, for example. Those are like a super brain food. So keeping in check the amount of added sugars and bad carbohydrates and bad fats that we have in our diet, that’s one aspect of it. Then targeting whatever particular hormonal pathway, or sometimes it’s multiple hormonal pathways that can be linked to that brain fog. And I said, if it’s post-menopausal, women definitely want to maybe go in and have your DHEA sulfate level tested many times. If your DHEA sulfate level’s incredibly low and you take a small dose supplement, maybe 25mg three or four days out of the week would be incredibly advantageous.† [00:07:55]
[00:07:56] Now, for significant amounts of brain fog, then we can look at other hormonal options, such as pregnenolone, but definitely DHEA. For many women who are going through that perimenopause and menopausal symptoms, they’ll find that when they add in just a small amount of DHEA, it helps to create an awful lot of balance for the brain, for your mood, for your adrenal glands because remember that DHEA is an adrenal hormone. So we want to take a food-based approach. We certainly want to utilize nutrients that we know can help wake that brain up. So that’s your rhodiola, things that are going to help those brain cells from getting dinged around, so that’s where your phosphatidylserine comes in. That resveratrol, which kind of goes in and through these different pathways works is like a little house cleaner goes in and make sure that where things are dunked up in your brain kind of goes in and scrubs it all away. So this is just a simplified approach to dealing with brain fog, which we know is much more common than we give it credit for. And we don’t want to allow things such as inflammation and hormonal imbalances to create havoc in our life. And if it’s on that aspect of histamine and maybe it’s an allergic component, then you’d want to look at things such as the Black Seed with Rosemary Extract. That is a wonderful way. Rosemary, we know, is incredibly beneficial when it comes to regulating how much histamine our body releases. So definitely think about it. Think about if you experience brain fog, maybe it comes and goes. Maybe you feel like you have chronic brain fog. There are many different nutrients that can help to support that mental fatigue and that cloudiness that you may be experiencing.† [00:09:47]
[00:09:48] So that is all that I have for you for today. I just want to thank you so much for tuning in to the InViteⓇ Health Podcast. Remember, you can find all of our episodes for free wherever you listen to podcasts or by visiting invitehealth.com/podcast. Now, do you make sure that you subscribe and that you leave us a review. You can follow us on Facebook, Twitter and Instagram, and we will see you next time for another episode of the InViteⓇ Health podcast.† [00:09:48]
*Exit music*
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Chronic Fatigue Syndrome: Can Anything Help?, Part 2 – InVite Health Podcast, Episode 490
chronic fatigue syndrome
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Please see below for a complete transcript of this episode.
Chronic Fatigue Syndrome: Can Anything Help?, Part 2 – InViteⓇ Health Podcast, Episode 490
Hosted by Jerry Hickey, Ph.
*Intro music*
InVite Health Podcast Intro: [00:00:04] Welcome to the InViteⓇ Health Podcast, where our degreed healthcare professionals are excited to offer you the most important health and wellness information you need to make informed choices about your health. You can learn more about the products discussed in each of these episodes and all that InViteⓇ Health has to offer at www.invitehealth.com/podcast. First time customers can use promo code PODCAST at checkout for an additional 15% off your first purchase. Let’s get started. [00:00:34]
Jerry Hickey, Ph.: [00:00:40] Welcome back to part two of my episode, Chronic Fatigue Syndrome: Can Anything Help? My name is Jerry Hickey. I’m a nutritional pharmacist. I’m also the Senior Scientific Officer over here at InViteⓇ Health. So welcome to the episode, and thanks for tuning in to this podcast today. You can find all of our episodes for free wherever you listen to a podcast or visit invitehealth.com/podcast. Subscribe and leave us a review, if you could. You can also follow us on Twitter, Instagram and Facebook @invitehealth, and the information on this episode is linked at the episode description.† [00:01:14]
[00:01:15] In part one, I spoke about typical treatments for chronic fatigue syndrome. I spoke about conditions that may be causative of it, how they tend to diagnose it, what tests, etc., and I explained that it was a diagnosis of exclusion. So there’s no test for chronic fatigue syndrome. What they have to do is rule out everything else that can lead to fatigue, such as alcoholism, such as insomnia, such as anemia, such as thyroid disease, such as having depression or anxiety, such as having cancer or some autoimmune disease, or something that can cause fatigue. So they rule out all those things. And if you’ve had that fatigue for six months or more persistently and you also have pain accompanying it, they probably will diagnose it as chronic fatigue syndrome. It’s also called myalgic encephalomyelitis.† [00:02:08]
[00:02:11] Now in part one, at the end, I spoke about cocoa and why cocoa might be helpful, but they found that cocoa in several small studies that it did help people with chronic fatigue syndrome, and I wouldn’t doubt it. I mean, there are ingredients in cocoa that probably would be helpful.† [00:02:26]
[00:02:28] But there’s also studies showing that probiotics and prebiotics help with chronic fatigue syndrome. Now, a probiotic are enough good bacteria that make a difference for your health. It’s a supplement, but you can also get in yogurt, and prebiotics are the food for them. Usually that comes out of chicory root. Chicory root is a cousin of Belgian endive and the good bacteria, by the way, love fiber. They love foods like lettuce and broccoli and spinach and beans. They love that kind of food. So that’s an easy way to feed them, right? So this is the journal Microbiome, which is a great journal. It’s all about bacteria. So, you know, the bacteria rule us. We have, it looks like well over 100 and… 100 trillion bacteria living with us, but they’re all over us. They’re in our lungs. They’re in our urinary tract. They’re in, they’re on our skin, they’re on our eyeballs, they’re on our scalp, they’re all over. But most of them are in our digestive tract. And the truth of the matter is we… If you took a square inch of our digestive tract, a square inch of our colon, our large intestine, there’s more bacteria living on that square inch of large intestine than all the people that were ever born on planet Earth. So who rules? So when you have a lot of bad bacteria, they inflame you. They cause problems. They can’t do the job the good bacteria do. And when you have good bacteria, it’s just the opposite. They reduce inflammation. They guide your immune system so they help prevent and even help reduce allergy reactions and allergies. They help guide your immune system towards fighting off viruses and infections and cancer cells. They do a lot of really good things, but strains matter. Species and strains matter. So not all species and strains can accomplish these things.† [00:04:34]
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[00:04:37] So here’s the journal Microbiome. And it’s Cornell University, and they said signs of chronic fatigue syndrome have been found in the gut bacteria in research conducted at Cornell University. So that raises the question, does chronic fatigue syndrome start in the brain? No, it might start in the intestines. They’re finding that with other brain diseases like Parkinson’s disease. There’s a lot of evidence now. It’s building, but the research hasn’t gotten around yet, but there’s a lot of studies if you look it up, that Parkinson’s disease, a movement disorder that occurs in the back of the brain that affects your, your gait the way you walk, it makes you stiff, it causes tremors, like your hand and your head shaking, that it starts in the gut. And there are studies in people with Alzheimer’s, when they give them certain strains of good bacteria, they help improve their brain function. So there really is a gut-brain axis. There were studies from Ireland and from Framingham State University, up in Massachusetts, etc., that certain probiotic bacteria help with mood and stress and anxiety, and possibly even depression. So, according to the Cornell University researchers, people with chronic fatigue syndrome, they constantly frequently have digestive tract issues, including irritable bowel syndrome. Irritable bowel syndrome is triggered by stress and anxiety and allergies, and you could be constipated. You could have diarrhea. You can have pain. So they found that when they gave probiotics in two studies, previous studies that there were marginal improvements in certain symptoms of people chronic fatigue syndrome. So the Cornell University researchers, they found that there are markers in your blood and your stool that indicate you have chronic fatigue syndrome. They found that certain bacteria are related to chronic fatigue and that lacking bacteria was connected with chronic fatigue. And they found that the bad bacteria create things that inflame you. And this is part and parcel, apparently, of chronic fatigue syndrome.† [00:07:05]
[00:07:06] They also found that it led to leaky gut syndrome. Now we’ve been talking about leaky gut syndrome in nutrition since the 1980s. What it is, you’re… There’s tight junctions between the cells that line your intestines, but it’s not very deep. It’s, it’s, it’s, it’s shallow. And if those junctions get loosened, things that shouldn’t get into the bloodstream, bloodstream are escaping from your digestive tract and entering your blood. So if your food is not totally digested and you have leaky gut syndrome, large molecules of food can escape into the bloodstream and then your immune system thinks that’s an infection and attacks it and that leads to food allergies. The leaky gut syndrome has also been connected to systemic lupus erythematosus, where your immune system is attacking your organs, rheumatoid arthritis, where your immune system is attacking your joints. They also find out a lack of healthy bacteria is connected, not just with chronic fatigue syndrome, but Crohn’s disease. So it wouldn’t hurt if you have chronic fatigue syndrome, myalgic encephalomyelitis, that you took a probiotic. It’s a good idea, and it wouldn’t hurt to try cocoa. It’s a good idea.† [00:08:31]
[00:08:33] So this is the journal of the British Dietetic Association. It’s called the Journal of Human Nutrition and Dietetics. It’s the School of Medical Sciences, Griffith University. Griffith University’s in Australia, and they’re looking at what helps chronic fatigue syndrome. So they’re doing a systematic review. With a systematic review, you go on all these electronic websites that collate research, and you fish through them to collect the data. So they found 17 studies, and they found that chronic fatigue was improved with cocoa. And they found that chronic fatigue was improved by probiotics. And they found that chronic fatigue was improved by NADH with coenzyme Q10. So we’re going to get to that right now. In fact, we make a product. I made a product years ago where we mixed the active version of coenzyme Q10 with NADH, so let’s talk about that. Let’s talk about what that is. A great deal of what you do for your energy is converting sugar into energy. It enters something called the Krebs citric acid cycle, and it creates energy. And that’s basically all the energy in your body, the energy for your brain, the energy to hear, the energy to see, the energy to smell and taste, the energy to digest food, the energy to walk, the energy to go to the bathroom, the energy for your immune system. It all comes out of that. Pretty much all of it.† [00:10:09]
[00:10:11] So CoQ10 is at the core of that. CoQ10 was discovered about fin de siecle, 19th century, 20th century. And a lot of research came out of Texas in the, in the 1950s. So Texas is like a hotbed of CoQ10 research. So we actually get the active form of CoQ10 from Texas, from Kaneka, which is a Japanese company, but they make it in Texas. It’s called Ubiquinol. And I think for people with chronic fatigue, rather than getting CoQ10, that’s poorly absorbed and hard to convert into the active form, they probably should get Ubiquinol. So we made Ubiquinol with NADH. NADH is a form of Vitamin B3 that’s extremely active. It’s an antioxidant. It’s involved with energy production and slowing down the aging process. It does a lot of wonderful things, but NADH also recycles Ubiquinol. So this is a randomized, double blind, placebo controlled human clinical trial. So it’s a state of the art gold standard human clinical trial. It’s in the journal Nutrients. It’s researchers from different research institutions in Spain. Twelve weeks long, 207 patients with chronic fatigue syndrome, and they split them into two groups. They received CoQ10 with NADH or matching placebo once daily. And you take that with food to absorb it. But once again, Ubiquinol is going to be superior because Ubiquinol is already active and typically people with these kind of syndromes, they don’t activate CoQ10 very effectively. So if we give the Ubiquinol, there’s a better chance it’s going to work for these people. But they used the regular CoQ10 in these people, but high quality CoQ10. They said there was a significant reduction in chronic fatigue overall, an improvement in their quality of life, the health-related quality of life. A real… And a real improvement also in sleep. They were sleeping better. They were sleeping longer. So the, the, the Ubiquinol or CoQ10 would really mean something.† [00:12:22]
[00:12:25] Now here’s another study. This is Antioxidant Redox Signaling. That’s a journal, and it’s Val de Hebron Research Institution and Val de Hebron University Hospital in Barcelona. And this is another eight week study, but this time it’s only 73 patients with chronic fatigue syndrome. And once again, they found if you gave them CoQ10 with NADH, there was a real improvement in their fatigue versus placebo. So in the bigger study, they also looked at sleep and sleep improved.† [00:12:59]
[00:13:03] Now, this is the RIKEN center for Bio Systemic Dynamic Research, it’s in Japan and this is in the journal Brain and Nerve, and they’re using PET scans, Positron Emission Tomography, magnetoencephalograms and Magnetic Resonance Imaging, that’s MRIs, to look at the brains of people with chronic fatigue syndrome. And they found that in parts of the brain involved with logic and memory and energy, etc., the brain was lacking Alcar. I’ll explain that in a minute. And they also found that they had inflammation in their brain. So people with chronic fatigue, I do give something called Alcar with ALA. ALA is involved with creating the energy molecule. Alcar delivers it into the cell. And there’s a lot of research that Alcar with ALA is good for energy, just like the CoQ10 with NADH is good for energy, and there’s a lot of research that Alcar with ALA is great for the brain. So it’s reasonable to give people with chronic fatigue syndrome something that’s fantastic for the brain, fantastic for the heart, fantastic for your muscles, such as the Ubiquinol and the Alcar with ALA.† [00:14:22]
[00:14:24] Here’s a study in people with chronic fatigue syndrome using Panax ginseng. I would skip that because you had to use really high doses, so I would skip that. I wouldn’t do it. It did seem to help them, but not a lot of research. Very few patients, only 50 patients and they had to use too big a dosage. They had to use 3000 milligrams every day. Even though I think it’s safe, I wouldn’t use it. They also found that people with chronic fatigue syndrome… This is Molecular Neurobiology. That’s Tir Na Nog. That’s an old Gaelic word, Tir Na Nog. It’s in Wales, you know, Wales in the UK. And they found that people with, I mean, this is very predictable people with chronic fatigue syndrome, not only did they lack Alcar like they found in the other study, they lack glutathione. So what’s glutathione? Glutathione is a master antioxidant enzyme. It protects the brain. It protects the eyes. It protects the heart. It protects your immune cells. It protects your red blood cells. It protects your pancreas and your kidneys and your liver. I mean, it’s just all over the body. But the amount of glutathione can vary dramatically from person to person because glutathione would help protect you from pollution, cigarette smoke, alcohol all these different things, infections. So they are finding that people with chronic fatigue syndrome lack glutathione and glutathione in the body strongly reduces inflammation.†[00:15:51]
[00:15:52] So here’s what I would do if I had chronic fatigue. All of these would be safe for you to try, and if you hit one that really helps, it’s going to make a difference. I would try cocoa. I would definitely try cocoa. Don’t put it in milk. Milk seems to reduce its effectiveness in general. Put it in water. Cocoa tastes great already, just put in water. I would try a great probiotic like Lactobacillus ramnosis, Lactobacillus plantarum, bifidobacterium animalis subspecies lactis, strains like that. I would use Ubiquinol with NADH. Ubiquinol’s active CoQ10. I would definitely use it. I would try… I would definitely try Alcar with ALA. I would definitely try glutathione, but you have to take a lot of glutathione. Possibly a better way for glutathione for your brain and protection is to take a supplement called NAC. It’s a precursor to glutathione that works really well. I would take NAC 600 milligrams three times a day with food and see if that helps you. [00:16:49]
[00:16:51] Now they’ve looked into B-vitamins, and they didn’t help people with chronic fatigue syndrome. But I don’t think they looked at the active forms of B-vitamins, and I haven’t seen studies where they’ve investigated if people with chronic fatigue syndrome can activate B-vitamins, so let’s discuss that. There’s different B-vitamins like B12, but the regular B12 they give people is cyanocobalamin, a synthetic form. Not everybody can convert that into the active form, which is methylcobalamin, which is the real form of the human body. So maybe that’s part of the problem. Or folic acid, synthetic B9, Vitamin B9. Not everybody can convert that to methyltetrahydrafolate, the active form. Or B6, pyridoxine hydrochloride. Not everybody can convert that to the active form pyridoxal 5 phosphate. So maybe with chronic fatigue syndrome, they need to look at, can these people activate B-vitamins, not just giving them the regular B-vitamins that you get on on the shelf in a, in a chain store pharmacy, but the active forms. Like we have Methyl-B, maybe they need to try that. Maybe it’ll help. It’s certainly not going to hurt because those B-vitamins lower the risk of cancer. The… When they’re activated, they lower the risk of Alzheimer’s disease. They’re good for your bones. They’re good for your heart. They’re good for your muscles. They’re great for energy. So maybe that’s part of the problem. Maybe they’re not looking in the right direction. Maybe they have to look at activating nutrients into their active form because if it’s not activated, it’s not going to help you. That’s why I said don’t use regular CoQ10, use Ubiquinol, it’s the active form of CoQ10.† [00:18:28]
[00:18:30] Now, I wouldn’t doubt that bio-curcumin, an active form of curcumin, turmeric, but the complete plant, that’s well absorbed would be helpful because it’s been shown to help with depression. It’s been shown to help with memory and brain energy. And since they’re finding that there’s inflammation in the brain of people with chronic fatigue syndrome, I would give that a shot. So let’s just review that. I’m going to say them quickly. I would definitely do cocoa. I would definitely try probiotics. I would definitely try Ubiquinol with NADH. I would try activated B-vitamins. I would try a well-absorbed turmeric like Bio-Curcumin or Curcumin Complex. I would try Alcar with ALA. They’re not going to hurt. They might help a great deal.† [00:19:17]
[00:19:20] Now there are other conditions that seem to be related to chronic fatigue syndrome, like fibromyalgia. Fibromyalgia is the most common muscle pain syndrome. People with fibromyalgia, even a breeze can hurt their face, picking up a cup of tea can hurt their hand. They have this magnified sense of pressure on their nociceptors. Nociceptors are nerves that, that feel pain and their nociceptors are way overactive. Irritable bowel syndrome is related. That’s a chronic condition, that means long lasting, that affects your large intestine that can lead to cramps and diarrhea and leaky gut syndrome and constipation, mononucleosis, infectious mononucleosis. But Epstein-Barr virus. So they have to really look at all these things Lyme disease, you know that tick-borne disease by the bacteria Borrelia burgdorfi… Burgdorferi, I should say. MS, hypothyroidism, so… But we’ve done podcast episodes on many of these, like fibromyalgia, hypothyroidism.† [00:20:25]
[00:20:31] So I want to thank you for tuning into the InViteⓇ Health Podcast today, you can find all of our episodes for free wherever you listen to podcasts or visit invitehealth.com/podcast. Please subscribe and leave us a review. You can also follow us on Facebook, Twitter and Instagram at @invitehealth. And I hope to see you next time on another, on another episode of the InViteⓇ Health Podcast. I want to thank you for listening. Jerry Hickey signing off.† [00:20:31]
*Exit music*
