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Please see below for a complete transcript of this episode.
Hosted by Amanda Williams, MPH
*Intro music*
InViteⓇ Health Podcast Intro: Welcome to the InViteⓇ Health Podcast, where our degreed healthcare professionals are excited to offer you the most important health and wellness information you need to make informed choices about your health. You can learn more about the products discussed in each of these episodes and all that InViteⓇ Health has to offer at www.invitehealth.com/podcast. First time customers can use promo code PODCAST at checkout for an additional 15% off your first purchase. Let’s get started!
*Intro music*
Amanda Williams, MPH:
[00:00:40] Teas have been widely consumed throughout the world, and we’ve all heard about the many potential health benefits that go along with tea. So today I want to zero in on tea and inflammation in the setting of arthritis. I’m Amanda Williams, M.D., M.P.H., and let’s get right to it. Let’s talk about the amazing amount of clinical research that is out there that is assessing the impact of the power nutrient, that power catechin coming from green tea, the EGCG and how beneficial that can be when it comes to targeting inflammation that’s directly associated with arthritis, so whether we’re looking at osteoarthritis or we are looking at rheumatoid arthritis.† [00:01:22]
[00:01:22] There was a very extensive research study that was published in the Life Science Journal back in 2010 that looked at the power of that polyphenol, that EGCG when it came to inflammation and arthritis. So being that we know that many Americans suffer from arthritic joints and arthritic conditions, this is an area that oftentimes people are looking for alternatives as opposed to using an NSAID on a daily basis, the non-steroidal anti-inflammatory drugs, because the long-term use of those in not so great, depending upon which one that you’re taking, can impact negatively different things, like acetaminophen, for example. The extended use of acetaminophen, definitely not a good thing for your liver. And then when you look at the other NSAIDs, such as ibuprofen, for example, then we have to start having concerns with the long-lasting negative impact on the kidneys.† [00:02:16]
[00:02:16] So that’s why I want to talk about green tea in this setting today and looking at the many benefits of how it is that green tea is really kind of guiding us through this inflammaging highway. So we… I talk oftentimes about inflammaging, which is accelerated aging brought on because of chronic inflammation. So understanding how the antioxidants that are contained within green tea can really target the inflammatory pathways in a much broader degree than we ever recognized previously. And one of the things that we now know from scientific research is that not only can that green tea help with the regulation of expression of different cytokines and chemokines and the reactive oxygen species and targeting, you know, COX-1 and COX-2 pathways. But we also now know that it targets something known as HMBG1, which is high mobility group box one. Why does that matter? Well, because when we understand the impact of HMGB1 in the body, then you can start to tie that in with the excessive amount of inflammation that can occur within the joints. So HMGB1 turns on the release of chemical signals in the body, which we call cytokines, and those cytokines generate up inflammation. So if we have this release of inflammatory cytokines, then over the course of time, so we’re talking chronic inflammation. In the acute setting, that’s one thing. You know, you stub your toe, you sprain your ankle. Acute inflammation is one thing, but we’re talking in the setting of chronic inflammation. Then we know we’ve got a big problem. So elevated HMGB1 levels have been found to be associated with many different chronic inflammatory conditions, so when we’re thinking about things such as arthritis. But we can also, you know, put into the mix different respiratory chronic conditions such as asthma, COPD, for example, we can look at inflammatory bowel disease, we can look at diabetes, for example, and many different conditions, even within the cardiovascular system, where you can see this elevation of HMGB1, which is a big problem.† [00:04:48]
[00:04:49] So what do we know now from the scientific studies is that the EGCG, the epigallocatechin gallate that’s coming from the green tea, this has been studied and shown to have this ability to inhibit that HMGB1, which is really incredibly powerful. So the first study that came out that really zeroed in on EGCG’s ability to do this was back in 2011, and that was in the Journal of Biochemical Pharmacology. So understanding that if we have a nutrient that’s coming from nature, so this power catechin, that EGCG. And this can actually work in a way to, in a sense, turn off that switch for inflammation, then we can start to see how it is that when you’re in a setting such as arthritis, why green tea can potentiate all of these powerful benefits. So I pulled a few different studies just to reinforce this, because it’s not like this was just a finding that they stumbled upon and then they let it go. No. They continue to look at this and said, “Wow, EGCG, you can actually down regulate the activation of this power signal, this HMGB1, which triggers this flood of cytokines to be released, which is significantly driving up inflammation.”† [00:06:04]
[00:06:06] So in the Life Science Journal, they go into many of the different components of green tea and how when you look at the scope of conditions to which green tea has been shown to be incredibly beneficial to you, when you think about green tea and cardiovascular disease and how green tea has been shown even at UCLA, University of California, Los Angeles to actually be able to lower the risk of stroke. And this was through a meta analysis that they did, and this was just through people who consumed a lot of tea. So drinking tea. So we’re not even talking about the power amount of EGCG that you get if you utilize Green Tea HxⓇ, for example. And they found that when people consumed three or more cups of tea per day, that they had a 20% lower risk of a stroke. And that’s just from, you know, something that they’re drinking every single day. Certainly, when you look at cognitive studies and what occurs within the brain, the aging brain and oxidative stress and how detrimental that can be to our cognition, this is another area of research where green tea is really shown to be incredibly beneficial when it comes to its immunomodulatory benefits. This is where you know, things like rheumatoid arthritis, looking at some of the issues that are arise with ulcerative colitis and Crohn’s disease, for example. So there’s just a vast amount of research out there that really zeroes in on just how powerful the use of EGCG can be when it comes to its vast, vast benefits.† [00:07:45]
[00:07:46] And of course, there’s a ton of studies looking at EGCG when it comes to cancer studies and cancer research. So when it’s cardiovascular, cancer, metabolic conditions such as diabetes, whether we’re looking at inflammation, we certainly can see how it is that the EGCG, potentially it’s this really powerful, powerful benefit. So in the Journal of Toxicology and Applied Pharmacology in 2017, they were looking at the anti-inflammatory activities of the green tea catechins when it came to these different signaling pathways in rheumatoid arthritis. So how do they set this up? While you have to test this in patients who have been diagnosed with rheumatoid arthritis, which is an autoimmune condition, and finding how the EGCG was incredibly effective in terms of inhibiting these downstream inflammatory signals. So we kind of go back to that high mobility group box one and you can see how that green tea really does pack a heck of a punch.† [00:08:49]
[00:08:50] In the Arthritis Research Therapeutics Journal in 2010, they also were looking at the progress of research, and so we’re talking over 10 years ago where they were looking at the progression of the scientific research that was coming out showing how the EGCG, the epigallocatechin gallate from the green tea, how this was creating an environment that was actually lowering inflammation in even the most severe cases of rheumatoid arthritis. Now, as I mentioned, you can also throw osteoarthritis into this mix, which is what most people have. Most people don’t have RA. Most people have osteoarthritis, and it’s key to be able to differentiate between the two. But the important takeaway from from that is to also recognize that whether we’re dealing with rheumatoid arthritis or we’re dealing with osteoarthritis, we’re dealing with significant amounts of inflammation. And so looking at the studies in patients who have RA is one thing, but they’ve also been able to show in patients that have your typical run-of-the-mill arthritis that the green tea and those powerful catechins do a wonderful job at being able to downregulate all of that inflammation.† [00:10:05]
[00:10:06] So, so much science out there. You can see the different pathways, whether we’re dealing with the same pathways that you’re non-steroidal anti-inflammatory drugs are targeting or, you know, even if we’re looking at some of the prescribed pain medications, the pathways to which those are working, the COX-1, COX-2 pathways, and obviously the more we can lessen our inflammation burden in the body, the more resolution we get to any type of a chronic condition. So addressing chronic inflammation is certainly important, and we understand the true benefit of getting green tea on board when it comes to partnering up in the, in the body and helping our body with managing that inflammation and a much more efficient way.† [00:10:53]
[00:10:53] I want to thank you so much for tuning in to the InViteⓇ Health Podcast. Remember, you can find all of our episodes for free wherever you listen to podcasts or by visiting invitehealth.com/podcast. Now do make sure that you subscribe and you leave us a review. You can follow us on Facebook, Twitter and Instagram, and we will see you next time for another episode of the InViteⓇ Health Podcast.† [00:10:53]
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You’ve probably heard that green tea is good for your immune system and respiratory health, but did you know it can also benefit your memory? Learn more from Jerry Hickey, Ph.
Chronic inflammation can wreak havoc on the body, so what can you do to help? Turn to powerful nutrients such as Vitamin D, resveratrol and more to help with inflammaging.
flu
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Please see below for a complete transcript of this episode.
Hosted by Jerry Hickey, Ph.
*Intro music*
InVite Health Podcast Intro: Welcome to the InViteⓇ Health Podcast, where our degreed healthcare professionals are excited to offer you the most important health and wellness information you need to make informed choices about your health. You can learn more about the products discussed in each of these episodes and all that InViteⓇ Health has to offer at www.invitehealth.com/podcast. First time customers can use promo code PODCAST at checkout for an additional 15% off your first purchase. Let’s get started!
*Intro music*
Jerry Hickey, Ph.:
[00:00:40] There’s an awful lot of research that green tea helps fight viruses. If you go into PubMed, the Library of Congress website that collates studies, and you type in “green tea” and the word “virus”, you’ll see many, many, many studies coming up. And right now we’re in flu season and we’re also in COVID-19 season. So can green tea help you with these? The answer seems to be, quite frankly, yes.† [00:01:11]
[00:01:13] So green tea is loaded with specific ingredients. There’re types of polyphenols. Now there’s thousands of polyphenols. For instance, the polyphenols in milk thistle are good for the liver and the kidneys. The polyphenols in grape seed extract are great for the heart and circulation. The polyphenols in resveratrol are great for the brain. Well, the polyphenols in green tea do many things. That’s because there are so many of them. There’s about 20 that we know of at this point. But the ones most involved with viruses are EGCG, also called Epigallocatechin gallate, and EGC, which is Epigallocatechin. So these are polyphenols and other polyphenols that are further broken down to flavanols, which there’s also thousands of, and from flavanols, they’re broken down to catechins. So the ingredients in green tea that are great for viruses are called catechins. So there’s different studies available that green tea may help slow down the Zika virus, that green tea might slow down particular hepatitis viruses that green tea slows down chikungunya virus. But there’s a lot of research that green tea slows down influenza, and it seems to be for all of the strains of the flu virus.† [00:02:39]
[00:02:43] So welcome to our episode, Update on Green Tea and the Flu. Hi, my name is Jerry Hickey. I’m a nutritional pharmacist. I’m also the Senior Scientific Officer over here, @invitehealth. You can find all of our episodes for free wherever you listen to podcasts or visit invitehealth.com/podcast. You can also follow us on Twitter, Instagram and Facebook @invitehealth. All of the information on today’s episode is linked at the episode description.† [00:03:13]
[00:03:14] So let’s just quickly in my brain review the studies on green tea and the flu. There is many studies out of Japan because, of course, Japan is famous for growing green tea, so they’re going to do research on green tea. Now, the health authorities in Japan tell people to gargle with water several times a day to lower their risk of the flu, and it actually works. Even just rinsing your mouth out with water several times a day reduces your risk of the flu. But if the children rinse their mouth with green tea, it very powerfully reduced their risk of the flu, we’re talking like a 65% reduction in the risk of having a diagnosis by a pediatrician for the flu in a child. There’s also studies in several precincts of Japan, where they have green tea plantations, and the children there tend to drink these tiny cups of green tea. And they found that there was a dose-response relationship, meaning the more green tea to a point, the lower their risk of having a sore throat and flu-like symptoms. And they found that the children who had up to five tiny little cups a day, had a much lower risk of developing fevers and sore throats and coughs, etc., symptoms related to flu and cold.† [00:04:33]
GREEN TEA AND LONGEVITY – INVITE HEALTH PODCAST, EPISODE 336. Listen Now>>
[00:04:35] Now, the University of Florida, Gainesville did a study, you know, the Gators, Gatorade. In any event, they did a study in American adults over a winter, and they gave them concentrated green tea capsules. And they found that far fewer of them developed the symptoms of the flu. Far fewer of them got sick. But for those who did get sick, they got better, a lot faster and their symptoms were much milder. So on one hand, it was lowering the risk of getting the flu. And on the other hand, if you did get it, it was like a weak infection. It didn’t mean as much as it could have. There’s a study in New York in healthcare professionals. They gave them green tea capsules, plus an element that comes out of green tea called L-theanine. And the incidence of colds and flu infections over the winter dropped dramatically in 200 healthcare professionals. There’s also research that green tea lowers the risk of getting infections in people in assisted living homes, what we used to call nursing homes. People are in assisted living homes for a reason. Maybe they had a stroke. Maybe they have a touch of Alzheimer’s. Maybe they had broken hips, but for some reason they’re weakened. They can’t take care of themselves anymore. Maybe they’re just extremely old and fragile. In any event, they get immunized for the flu, but it doesn’t mean that much because their immune system is getting old and not as functional anymore, so they don’t make enough antibodies to the flu. So these were a whole group of people in assisted living homes who were immunized for the flu. If they gave them green tea after that, it further cut down on the risk of the flu by about 75% because they could still get the flu because, like I said, their immune system is becoming slowed down and weakened and compromised, and that’s just not working effectively, even if they get immunized. So there is a lot of studies. In fact, there was this other study from Japan. Older women that supped a lot of green tea had a much lower risk of dying from pneumonia. So there’s a lot of data looking at green tea and the flu.† [00:06:56][00:07:00] So this is a very recent review and a meta analysis. They went through all of these web sites that collate research and hunted for new research on green tea and influenza, green tea and the flu. It’s from the Biological Science Research Labs in Tokyo, Japan, and the Graduate School of Pharmaceutical Sciences, Shizuka University in Japan. They do a lot of great research there. It’s an, it’s published in the European Journal of Nutrition. So they’re looking for studies specific to green tea and the flu. And they found six randomized, placebo-controlled human clinical trials and four prospective cohort studies. Prospective cohort studies are very interesting to me. They get a large population of people. So maybe they’ll get 30,000 people in Seattle, Washington, and then they’ll look at all of their health data and the way they eat and do they take vitamins and do they have any illnesses, and they follow them for years and you get a huge amount of data out of that. You could get data on, you know, what increases your risk of diabetes or what increases the risk of breast cancer or prostate cancer. So they, they, they really data mine for all these different things because if you look at 30, 40,000 people, you could get a lot of data out of it. So in this case, there were four of those studies, four huge population based cohort studies, looking does green tea lower the risk of of viruses and the flu? And six randomized, placebo-controlled human clinical trials, which are gold standard state of the art studies. And they found that green tea catechins, that’s the EGCG and the EGC, those two especially, inhibit the spread of viruses by creating a protective sort of barrier in your pharynx. So what’s your pharynx? In the back of your mouth, your throat bends down to your esophagus. The esophagus is the tube from your throat down to your stomach. That bend is called a pharynx. So apparently drinking green tea kind of stops the viruses from getting past the pharynx. Well, that’s a good thing. And they also found in all these studies that green tea strongly reduces the risk of upper respiratory tract infections. So what’s the upper respiratory tract? Well, the nose, the mouth, the nasal pharynx, that area, so that could be a sore throat, a cold, stuffy nose. They found that EGCG and EGC, these are two of the primary catechins in green tea, bind to hemagglutinin, the spike of hemagglutinin on the outside of the viral envelope, and neuraminidase. Now that’s really interesting. These are enzymes that the virus uses to cling on to you. So somebody sneezes on you, the virus hits you, it’s got to hold on. It’s got to penetrate into the cell, multiply and spread from cell to cell. And they found that green tea inhibited these enzymes. In other words, green tea was preventing influenza. They’re looking at influenza. And the more green tea you consume, the better you’re protected. So once again, there’s a dose response. One cup of green tea is protective. Two cups, two cups of green tea a day, not at the same time, are more protective, and three cups is even better. So the more green tea you consume, the better you’re protected from all flu strains, all flu strains.† [00:10:46]
[00:10:47] So now let’s look at coronavirus. Coronavirus is actually a family of viruses, like there’s a bunch of colds in the United States caused by something like five different strains of coronavirus. But the one we’re concerned with now is the SARS-CoV-2 virus that causes COVID-19. That’s the name of infection, but the virus is actually called SARS-CoV-2. So this is Yonsei University in Korea. That’s a pre-clinical study. A pre-clinical study means it’s not in people. That’s in the journal Viruses. So the first part is in vitro, which means it’s in a dish, it’s not in something living. Green tea blocked the ability of the coronavirus to infect cells by blocking its infectious enzymes like hemagglutinin, like green tea was doing with the flu in the other study. Then they did an in-vivo study. In-vivo means something living, like a rabbit or a hamster or a mouse or a rat. So in this case, it was mice and they infected the poor mice with coronavirus. If they gave them green tea with greater than 60%t catechins, but also rich in EGCG… So if it was just 60% catechins or it was just very powerful EGCG, either one of them blocked coronavirus, it blocked human coronavirus to a very good degree, but it also kept the virus out of the lungs of the mice.† [00:12:22]
[00:12:24] So here’s the Department of Virology, Paul Ehrlich Institute, that’s in Germany, and the German Center for Infection Research. It’s in the Journal of General Virology. And they found that green tea and especially EGCG blocked COVID-19. It was blocking the spike protein, it was blocking the ability of COVID-19 to infect you. But here’s the interesting thing. Before COVID-19, years ago, there was MERS. That was in the Middle East like Saudi Arabia, and there was the original SARS virus, the SARS-COVID virus. This is SARS-CoV-2. This is the latest strain. And they found that green tea also inhibited MERS and SARS-COVID, the original viruses.† [00:13:25]
[00:13:27] So here’s the journal Molecules. It’s the Department of Immunology, Kyoto Prefectural University of Medicine and The Central Research Institute, both in Japan. And when they exposed COVID-19 virus to green tea, it reduced the detectable number of virus cells to one one-hundredth. And it killed 99%, on contact, of the COVID-19 virus. It killed 99%. Now, then they went a further step. They took the EGCG, green tea rich in EGCG, that’s the major polyphenol. That’s the one that’s looked at for prostate cancer and breast cancer and colon cancer and aging and muscle health and brain health, et cetera. They took green tea very rich in EGCG, and they also added some black tea to theaflavins. This is what we did in our Green Tea HxⓇ capsule, by the way. This was even stronger against COVID-19. Reduced infectivity have made it harder for the virus to infect the cells. It reduced viral replication, the virus couldn’t spread. The virus couldn’t reproduce, and it also inhibited the spread of virus from cell to cell. There really seems to be something about green tea and viruses.† [00:14:50]
[00:14:52] Now, I just did an update on Vitamin D and COVID-19. And now I’m doing an update on green tea and mostly influenza, but possibly an effect on COVID-19. So why not sip green tea? It’s delicious. It’s healthy. I would do a minimum of three cups a day. I would brew it and let it cool down. Don’t add sugar and don’t add milk to it. Add lemon. It kind of protects the green tea catechins, and you absorb them better, and the more you absorb, the better it is for your health. So I would definitely get my Vitamin D levels higher right now, because there’s a lot of evidence that it keeps you safer from COVID-19. And I would definitely be sipping green tea.† [00:15:37]
[00:15:39] So thank you for listening to today’s InViteⓇ Health Podcast broadcast, you can find all of our episodes for free wherever you listen to podcasts or just visit invitehealth.com/podcast. You can also follow us on Twitter, Instagram and Facebook at @invitehealth. And by the way, when you listen to our podcast, if you could subscribe and leave us a review, it would be helpful. I want to thank you for listening. I’m signing off, Jerry Hickey. Hope to see you next time on another InViteⓇ Health Podcast episode.† [00:15:39]
*Exit music*
